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Correlation between image-defined risk factors and surgical complications in patients with neuroblastoma: a retrospective study

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Abstract

Background

Image-defined risk factor (IDRF) is a common tool used for neuroblastoma risk group classification. We speculated that anatomical evaluation by IDRF might be correlated with surgical complications and the oncologic outcome. Here, we investigated correlation between IDRF with outcomes of surgery of neuroblastoma patients.

Methods

Medical records and computed tomography images of neuroblastoma patients who underwent a surgery at Songklanagarind Hospital between 2002 and 2019 were retrospectively reviewed. IDRFs were analyzed for correlation with surgical complications, overall survival, progression-free survival and local recurrence within 2 years.

Results

Forty-five patients were enrolled in the study. Sixteen (35%) patients had low IDRF score at diagnosis (score ≤ 5). Other 29 (64%) patients had high IDRF score (score ≥ 6). High IDRF group significantly had higher incidence of organ injury and more intraoperative blood loss. At post-chemotherapy, high IDRF was not only associated with higher operative complications, but also associated with 2-year overall survival and progress-free survival.

Conclusions

Neuroblastoma patients whose IDRF score, either at diagnosis or after neoadjuvant therapy, was 6 or higher had increased risk of surgical complication. This evidence prompts pediatric surgeons to prepare more for safe surgery in this group of patients.

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Data availability

Anonymized data used in our study can be provided upon request to Professor Surasak Sangkhathat (surasak.sa@psu.ac.th).

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Acknowledgements

This research was supported by the National Science, Research and Innovation Fund (NSRF) and Prince of Songkla University, Thailand [grant number MED65051955]. We would also like to express our gratitude to Mr. Dave Patterson who edited English language in the manuscript.

Funding

The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Division of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Poowanon Saksiri & Surasak Sangkhathat

  2. Division of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Pornpan Sripornsawan

  3. Division of Radiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Supika Kritsaneepaiboon

  4. Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Wison Laochareonsuk, Pongsakorn Choochuen & Surasak Sangkhathat

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  1. Poowanon Saksiri
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Contributions

The manuscript has been read and approved for submission by all the named authors. I also confirmed that all the authors contributed equally in this study. SS and WL conceived of study concept, design and directed the study. PS, WL, PS and SK contributed to data acquisition, performed data analysis and result interpretation. PS, PC and SS drafted the manuscript and designed the figures. SS, SK and PC reviewed and revised the manuscript. All the authors provided critical feedback and helped shape the research, analysis and manuscript.

Corresponding author

Correspondence to Surasak Sangkhathat.

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Competing interests

The authors declare no competing interests.

Ethical approval

All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Human Research Ethics Committee of the Faculty of Medicine, Prince of Songkla University (REC.63-210-10-4).

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Saksiri, P., Sripornsawan, P., Kritsaneepaiboon, S. et al. Correlation between image-defined risk factors and surgical complications in patients with neuroblastoma: a retrospective study. Pediatr Surg Int 39, 70 (2023). https://doi.org/10.1007/s00383-022-05361-2

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  • DOI: https://doi.org/10.1007/s00383-022-05361-2

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