Abstract
Purpose
To assess real-world educational outcomes, neurodevelopmental disorders and mental health disorders in patients with intestinal atresia (IA) and compare these to outcomes to age-matched controls.
Methods
We performed a retrospective case–control study of children with IA born between 1991 and 2017. We evaluated educational outcomes using an Early Developmental Instrument, Grades 3, 7 and 8 assessments, Grade 9 completion and performance, high school graduation, and neurodevelopmental and mental health disorders using International Classification of Diseases codes available from a population-based dataset.
Results
We identified a total of 94 IA cases and 940 date-of-birth-matched controls. Cases with chromosomal anomalies were more likely to fail the Early Developmental Instrument (OR = 2.88, p = 0.037), Grade 8 reading (OR = 2.94, p = 0.043) and Grade 12 (OR = 3.25, p = 0.036); cases without chromosomal anomalies were at no greater risk than their peers of failing to meet expectations and did not have an increased risk of anxiety (OR = 0.48, p = 0.12), depression (OR = 0.74, p = 0.6) or hyperactivity disorder (OR = 1.92, p = 0.087).
Conclusions
Our study demonstrated that IA patients without chromosomal anomalies are not at higher risk of neurodevelopmental and mental health disorders than controls. These results will offer more accurate outcome predictions for parents of children with IA.
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Data availability
The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.
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Acknowledgements
The authors acknowledge the generosity of the patients and pediatric surgeons of the HSC-Children’s Hospital whose experiences made this study possible. This work was supported by grants from the DEVOTION Network and the Children’s Hospital Research Institute of Manitoba as well as Project Grant PJT-178387 from the Canadian Institutes of Health Research. Dr. Richard Keijzer is the Thorlakson Chair in Surgical Research for the Department of Surgery and the University of Manitoba. The authors acknowledge the Manitoba Centre for Health Policy for use of data contained in the Manitoba Population Research Data Repository under project # 2017/2018-29. The results and conclusions are those of the authors and no official endorsement by the Manitoba Centre for Health Policy, Manitoba Health, or other data providers are intended or should be inferred. Data used in this study are from the Manitoba Population Research Data Repository housed at the Manitoba Centre for Health Policy, University of Manitoba, and were derived from data provided by Manitoba Health.
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YM, SLM and RK designed the study YM and SLM analyzed the data YM, SLM and RK wrote the manuscript YM, SLM, AY and RK critically reviewed and revised the manuscript.
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Miyake, Y., Lum Min, S.A., Yamataka, A. et al. The impact of intestinal atresia on educational and mental health outcomes in school-aged children: A case–control cohort study. Pediatr Surg Int 39, 86 (2023). https://doi.org/10.1007/s00383-022-05357-y
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DOI: https://doi.org/10.1007/s00383-022-05357-y