Abstract
Objective
The aim of this study was to report on the short-and long-term outcomes of surgery for chronic pancreatitis (CP) in children.
Methods
All the children, who underwent surgery for CP between August 2007 and July 2019 in the Department of Surgical gastroenterology, Institute of Postgraduate Medical Education and Research, Kolkata, India were retrospectively reviewed.
Results
Of the total 54 patients, 33 (61%) were girls. The median age at operation was 16.5 years. The median duration between onset of pain and surgery was 36 months. 26% of patients were referred after failure of endotherapy. The most common indication for surgery was pain (94%). Surgery performed included modified Puestow (n = 26), Frey (n = 25), and Izbicki procedures. Twelve postoperative complications developed in ten (18.5%) patients. Most common complication was wound infection. Pancreatic leak developed in four (7.4%) patients (type A = 3, type B = 1). Median postoperative hospital stay was 8 days. There was no in-hospital mortality. Over a median follow-up of 48 months, 83% of patients had complete pain control. Weight gain was achieved in 77% of patients. New-onset diabetes and exocrine insufficiency developed in 4 and 14% of patients, respectively.
Conclusions
Surgery is safe with fairly acceptable perioperative complications and good long-term pain control.
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References
Frey CF, Mayer KL (2003) Comparison of local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy (Frey procedure) and duodenum-preserving resection of the pancreatic head (Beger procedure). World J Surg 27(11):1217–1230
Rollins MD, Meyers RL (2004) Frey procedure for surgical management of chronic pancreatitis in children. J Pediatr Surg 39(6):817–820
Roch AM, Brachet D, Lermite E, Pessaux P, Arnaud JP (2012) Frey procedure in patients with chronic pancreatitis: short and long-term outcome from a prospective study. J Gastrointest Surg 16(7):1362–1369
Bradley EL III (1987) Long-term results of pancreatojejunostomy in patients with chronic pancreatitis. Am J Surg 153:207–213
Sudo T, Murakami Y, Uemura K et al (2014) Short- and long-term results of lateral pancreaticojejunostomy for chronic pancreatitis: a retrospective Japanese single-center study. J Hepatobiliary Pancreat Sci 21(6):426–432. https://doi.org/10.1002/jhbp.48
Negi S, Singh A, Chaudhary A (2010) Pain relief after Frey's procedure for chronic pancreatitis. Br J Surg 97(7):1087–1095. https://doi.org/10.1002/bjs.7042
Ueda J, Miyasaka Y, Ohtsuka T, Takahata S, Tanaka M (2015) Short- and long-term results of the Frey procedure for chronic pancreatitis. J Hepatobiliary Pancreat Sci 22(3):211–216. https://doi.org/10.1002/jhbp.176
Bachmann K, Tomkoetter L, Kutup A et al (2013) Is the Whipple procedure harmful for long-term outcome in treatment of chronic pancreatitis? 15-years follow-up comparing the outcome after pylorus-preserving pancreatoduodenectomy and Frey procedure in chronic pancreatitis. Ann Surg 258(5):815–821. https://doi.org/10.1097/SLA.0b013e3182a655a8
Bachmann K, Tomkoetter L, Erbes J et al (2014) Beger and Frey procedures for treatment of chronic pancreatitis: comparison of outcomes at 16-year follow-up. J Am Coll Surg 219(2):208–216. https://doi.org/10.1016/j.jamcollsurg.2014.03.040
Yekebas EF, Bogoevski D, Honarpisheh H et al (2006) Long-term follow-up in small duct chronic pancreatitis: a plea for extended drainage by "V-shaped excision" of the anterior aspect of the pancreas. Ann Surg 244(6):940–948. https://doi.org/10.1097/01.sla.0000246914.25884.e9
Hodgman E, Megison S, Murphy JT (2019) Puestow procedure for the management of pediatric chronic pancreatitis. Eur J Pediatr Surg 29(2):153–158. https://doi.org/10.1055/s-0037-1608938
Laje P, Adzick NS (2013) Modified Puestow procedure for the management of chronic pancreatitis in children. J Pediatr Surg 48(11):2271–2275. https://doi.org/10.1016/j.jpedsurg.2013.03.048
Sacco Casamassima MG, Goldstein SD, Yang J et al (2017) The impact of surgical strategies on outcomes for pediatric chronic pancreatitis. Pediatr Surg Int 33(1):75–83. https://doi.org/10.1007/s00383-016-3999-6
Clifton MS, Pelayo JC, Cortes RA et al (2007) Surgical treatment of childhood recurrentpancreatitis. J Pediatr Surg 42(7):12031207. https://doi.org/10.1016/j.jpedsurg.2007.02.009
Bassi C, Marchegiani G, Dervenis C et al (2017) The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery 161(3):584–591. https://doi.org/10.1016/j.surg.2016.11.014
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. AnnSurg 240(2):205–213. https://doi.org/10.1097/01.sla.0000133083.54934.ae
Chiu B, Lopoo J, Superina RA (2006) Longitudinal pancreaticojejunostomy and selective biliary diversion for chronic pancreatitis in children. J Pediatr Surg 41(5):946–949. https://doi.org/10.1016/j.jpedsurg.2006.01.015
Chromik AM, Seelig MH, Saewe B et al (2008) Tailored resective pancreatic surgery for pediatric patients with chronic pancreatitis. J Pediatr Surg 43(4):634–643. https://doi.org/10.1016/j.jpedsurg.2007.12.004
Weber TR, Keller MS (2001) Operative management of chronic pancreatitis in children. Arch Surg 136(5):550–554. https://doi.org/10.1001/archsurg.136.5.550
Chaudhary A, Negi SS, Masood S, Thombare M (2004) Complications after Frey's procedure for chronic pancreatitis. Am J Surg 188(3):277–281
Ray S, Sanyal S, Ghatak S et al (2015) Frey procedure for chronic pancreatitis in children: a single center experience. J Pediatr Surg 50(11):1850–1853. https://doi.org/10.1016/j.jpedsurg.2015.07.012
Nealon WH, Walser E (2003) Duct drainage alone is sufficient in the operative management of pancreatic pseudocyst in patients with chronic pancreatitis. Ann Surg 237(5):614–622. https://doi.org/10.1097/01.SLA.0000064360.14269.EF
Ahmed Ali U, Nieuwenhuijs VB, van Eijck CH et al (2012) Clinical outcome in relation to timing of surgery in chronic pancreatitis: a nomogram to predict pain relief. Arch Surg 147(10):925–932. https://doi.org/10.1001/archsurg.2012.1094
van der Gaag NA, van Gulik TM, Busch OR et al (2012) Functional and medical outcomes after tailored surgery for pain due to chronic pancreatitis. Ann Surg 255(4):763–770. https://doi.org/10.1097/SLA.0b013e31824b7697
Li SJ, Tan CL, Tian BL (2017) Risk factors for pain after Frey's procedure in chronic pancreatitis. Medicine (Baltimore) 96(36):e7675. https://doi.org/10.1097/MD.0000000000007675
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SR wrote and drafted the manuscript; ZA, DK, KJ, SK were involved in literature search and critically revised the manuscript. All authors had read and approved the final manuscript.
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Ray, S., Ansari, Z., Kumar, D. et al. Short- and long-term outcome of surgery for chronic pancreatitis in children: a single surgeon experience. Pediatr Surg Int 36, 1087–1092 (2020). https://doi.org/10.1007/s00383-020-04691-3
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DOI: https://doi.org/10.1007/s00383-020-04691-3