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Extracranial metastasis of pediatric glioblastoma: case report and literature review

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Abstract

Glioblastoma (GBM) is a rare primary brain tumor in children, and extracranial metastases of pediatric GBM are particularly uncommon. We present the case of a 10-year-old girl with pediatric GBM who developed multiple extracranial metastases, including cervical lymph nodes, spine, and lung. We discuss the rarity of extracranial metastases in GBM and explore possible mechanisms of dissemination. The patient underwent surgical resections, radiotherapy, and chemotherapy, but the metastatic disease progressed despite treatment. We emphasize the need to consider extracranial metastases in pediatric GBM patients and adopt multimodal treatment approaches for managing this rare clinical entity. As the survival rates of pediatric GBM patients are improving, awareness of extracranial metastases is crucial for optimizing treatment outcomes.

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Authors and Affiliations

  1. Department of Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan

    Wei-Zhi Huang

  2. Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan

    Hung-Chieh Chen

  3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Hung-Chieh Chen

  4. Section of Pediatric Hematology, China Medical University Children’s Hospital, Taichung, Taiwan

    Te-Kau Chang

  5. Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan

    Weir Chiang You

  6. Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    Yee-Jee Jan

  7. Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Taichung, 407, Taiwan

    Yu-Cheng Chou

  8. Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan

    Yu-Cheng Chou

  9. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan

    Yu-Cheng Chou

  10. Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

    Yu-Cheng Chou

Authors
  1. Wei-Zhi Huang
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  2. Hung-Chieh Chen
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  3. Te-Kau Chang
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  4. Weir Chiang You
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Contributions

Wei-Zhi Huang, Hung-Chieh Chen, and Yu-Cheng Chou conceptualized and drafted the manuscript. Hung-Chieh Chen also edited the manuscript. Yu-Cheng Chou revised the manuscript and supervised the research work. Te-Kau Chang reviewed the literature and performed chemotherapy. Weir Chiang You reviewed the literature and performed radiotherapy. Yee-Jee Jan made the histopathologic diagnosis and reviewed the literature.

Corresponding author

Correspondence to Yu-Cheng Chou.

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Competing interests

The authors declare no competing interests.

Ethics approval

This study was conducted in accordance with the Declaration of Helsinki. The study was approved by the Institutional Review Board (IRB) of Taichung Veterans General Hospital (IRB: CE19140B).

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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Huang, WZ., Chen, HC., Chang, TK. et al. Extracranial metastasis of pediatric glioblastoma: case report and literature review. Childs Nerv Syst 40, 933–937 (2024). https://doi.org/10.1007/s00381-023-06229-z

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  • DOI: https://doi.org/10.1007/s00381-023-06229-z

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