Abstract
Background
Gangliogliomas are rare mixed neuronal-glial tumors of the central nervous system, accounting for less than 2% of intracranial tumors.
Case description
This report presents a rare case of ganglioglioma in the sellar region of a 3-year-old and 5-month-old pediatric patient. The patient underwent surgical intervention initially through a transnasal transsphenoidal approach and subsequently through a transcranial pterional craniotomy approach. Subsequently, radiotherapy and chemotherapy were administered for residual tumor tissue. The purpose of this report is to highlight the presence of ganglioglioma as a distinct diagnosis in sellar region tumors, discuss the surgical, radiotherapy, and/or chemotherapy treatment options for sellar region gangliogliomas based on the literature, and contribute the patient’s follow-up and treatment outcomes to the existing literature.
Conclusion
Complete tumor resection may not be feasible in sellar region gangliogliomas, especially in pediatric cases, due to endocrinological and vision-related complications. In cases where complete resection is not possible, radiotherapy and/or chemotherapy may be considered. However, the optimal treatment approach has not yet been established, and further research is needed.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [Buruc Erkan], [Suat Demir], [Ebubekir Akpinar] and [Tuce Soylemez Akkurt]. The first draft of the manuscript was written by [Buruc Erkan], [Suat Demir], [Osman Tanriverdi], [Omur Gunaldi] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Erkan, B., Demir, S., Akpinar, E. et al. A rare tumor in the sellar region: ganglioglioma, a case report and a general overview. Childs Nerv Syst 39, 3621–3626 (2023). https://doi.org/10.1007/s00381-023-06073-1
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DOI: https://doi.org/10.1007/s00381-023-06073-1