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Pediatric synchronous multifocal and disseminated cerebrospinal classic medulloblastoma revealed by bilateral decreased visual acuity: a case report

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Abstract

Medulloblastoma (MB) is a rapidly growing malignant solid tumor that arises from stem cells located in the subependymal germinal matrix or outer granular layer of the cerebellum. It represents 15 to 30% of pediatric brain tumors and less than 1% of primary brain tumors. The reason for the high incidence of MB in children compared to adults is the embryonic origin of the tumor. In typical cases, MB manifests as a solitary lesion in the fourth ventricle or in the cerebellar parenchyma; cases of synchronous multifocal and disseminated MB are quite rare in patients without familial tumor syndromes. To date, only 7 cases in adults and a single pediatric case with Gorlin syndrome have been described previously. Here, the authors report a new case of synchronous multifocal classic cerebrospinal histologically confirmed MB in a 10-year-old male patient revealed by bilateral decreased visual acuity without any other localizing neurological signs. The authors will proceed with a review of the current literature regarding this rare entity.

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Authors and Affiliations

  1. Department of Neurosurgery, UHC Habib Bourguiba, Sfax, Tunisia

    Mehdi Borni, Souhir Abdelmouleh, Ines Cherif, Hatem Daoud & Mohamed Zaher Boudawara

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  1. Mehdi Borni
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  2. Souhir Abdelmouleh
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  3. Ines Cherif
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  4. Hatem Daoud
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  5. Mohamed Zaher Boudawara
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Correspondence to Mehdi Borni.

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Borni, M., Abdelmouleh, S., Cherif, I. et al. Pediatric synchronous multifocal and disseminated cerebrospinal classic medulloblastoma revealed by bilateral decreased visual acuity: a case report. Childs Nerv Syst 38, 2211–2215 (2022). https://doi.org/10.1007/s00381-022-05546-z

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  • DOI: https://doi.org/10.1007/s00381-022-05546-z

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