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Clinical features and prognostic significance of tumor involved with subventricular zone in pediatric glioblastoma: a 10-year experience in a single hospital

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Abstract

Purpose

Tumors involved with subventricular zone (SVZ) predicted an adverse prognosis had been well proved in adult glioblastoma (GBM). However, we still know less about its impact on children due to the rarity of pediatric glioblastoma (pGBM). We performed this retrospective study to better understand the clinical and prognostic features of pGBM involved with SVZ.

Methods

Fifty-two patients diagnosed with pGBM at our center between January 2011 and January 2021 were selected for review to demonstrate the characteristics of tumor contacting SVZ. Thirty patients who underwent concurrent chemoradiotherapy and adjuvant chemotherapy postoperatively were selected for survival analysis.

Results

Of all the 52 patients, 21 were found to contact SVZ and 31 were not. The median PFS and OS in SVZ + patients were 5.2 and 8.9 months, respectively, whereas median PFS and OS were 11.9 and 17.9 months, respectively, in SVZ − patients. Multivariate analysis showed that involvement of SVZ was an independent prognostic factor for OS while focality at diagnosis was an independent prognostic factor for PFS. Tumors contacted with SVZ tend to have larger volumes, lower incidence of epilepsy, and lower total resect rate and they were more likely to originate from midline location. Age at diagnosis; gender; adjuvant therapy; focality at diagnosis; focality at relapse; mutational status of H3K27M, MGMT, IDH1, and IDH2; and expression of P53 and ATRX protein failed to characterize SVZ + patients.

Conclusion

Involvement of SVZ predicted worse OS in pGBM and it had some distinct clinical features in comparison with those that did not contact with SVZ. Multifocal tumor at diagnosis was related to a shorter PFS. We should make a further step to clarify its molecular features.

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Availability of data and material

The datasets used during the current study are available from the corresponding author on reasonable request.

Abbreviations

SVZ:

Subventricular zone

MID:

Midline

HEM:

Hemisphere

pGBM:

Pediatric glioblastoma

GBM:

Glioblastoma

HGGs:

High-grade gliomas

PFS:

Progression-free survival

OS:

Overall survival

EOR:

Extent of resection

RT:

Radiotherapy

CT:

Chemotherapy

MRI:

Magnetic resonance imaging

IDH:

***Isocitrate dehydrogenase

DWI:

Diffusion-weighted images

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Acknowledgements

We thank all the patients who trusted us and all the physicians and staff who helped this study and authors whose work was referred or quoted in this study.

Funding

This study is supported by the Medical Science and Technology Project of Henan Province (SBGJ202003032).

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Authors and Affiliations

  1. Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Jianshe East Road No 1Henan Province, Zhengzhou, 450000, People’s Republic of China

    Yang Jiao, Meng Wang, Xueyou Liu, Junkuan Wang & Hongwei Sun

  2. Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Yuwei Shou

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  1. Yang Jiao
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  2. Meng Wang
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Contributions

Yang Jiao: conceptualization, data curation, writing (original draft preparation); Meng Wang: writing (reviewing and editing); Xueyou Liu: writing (reviewing and editing); Junkuan Wang: writing (reviewing and editing); Yuwei Shou: data curation; Hongwei Sun: supervision, writing (reviewing and editing).

Corresponding author

Correspondence to Hongwei Sun.

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Ethics approval

The implementation of this study has been approved by the ethics committee of the First Affiliated Hospital of Zhengzhou University. The use of data for analysis has been agreed by guardians of every child involved in this study.

Consent to participate

Consent to participate in our study had been obtained from parents of every patient. 

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Written informed consent for publication was obtained from all participants.

Conflict of interest

Neither I nor my spouse/partner has a commercial interest, financial interest, and/or other relationship with manufacturers of pharmaceuticals, laboratory supplies, and/or medical devices or with commercial providers of medically related services.

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Jiao, Y., Wang, M., Liu, X. et al. Clinical features and prognostic significance of tumor involved with subventricular zone in pediatric glioblastoma: a 10-year experience in a single hospital. Childs Nerv Syst 38, 1469–1477 (2022). https://doi.org/10.1007/s00381-022-05522-7

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  • DOI: https://doi.org/10.1007/s00381-022-05522-7

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