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Pediatric meningiomas: a report of 5 cases and review of literature

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Abstract

Purpose

The purpose of this paper is to provide novel insight into the rare pediatric meningiomas.

Methods

We retrospectively analyzed pediatric surgical cases of meningioma during 2002 to 2017 in our institution. The preoperative, intraoperative, and the postoperative status were collected to find any unique features that has not reported in the past.

Results

Nine surgeries out of 5 patients were identified. The mean age was 7 years old (range 1–14 years old). Four patients were females. The mean tumor diameter was 52 mm (range 23–81 mm). The tumor locations were optic nerve sheath, Sylvian fissure, parasagittal, trigone of the lateral ventricle, and cerebellopontine angle. The Sylvian fissure meningioma without dural attachment (MWODA) was found in a 15-month-old female. A relapsed parasagittal meningioma showed regression in histological grade and residual tumor demonstrated spontaneous regression. In the initial surgeries, Simpson grade 1 resection was achieved in 2 cases. The pathological diagnoses were 1 meningothelial, 1 metaplastic, 2 atypical, and 1 clear cell meningiomas. The mean postoperative follow-up period was 71 months. Three patients experienced recurrence of the tumor. At the latest follow-up, all patients were free of radiological tumor recurrence or regrowth with a mean follow-up of 4 years (range 1–6.9 years). All patients were in the modified Rankin scale of 0–1.

Conclusions

MWODA is not considered to be rare in pediatric meningioma and should be included in the differential diagnosis. We presented a histologically regressed relapsed meningioma, which spontaneously regressed after subtotal resection. In the case of recurrent meningioma, surgical resection and adjuvant radiation therapy could be effective for long-term control of the tumor.

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References

  1. Miranda P, Simal JA, Vila M, Hernandez M, Menor F, Alvarez-Garijo JA (2009) Posterior fossa clear cell meningioma without dural attachment in a child. Childs Nerv Syst 25:389–392

    Article  Google Scholar 

  2. Kohama I, Sohma T, Nunomura K, Igarashi K, Ishikawa A (1996) Intraparenchymal meningioma in an infant--case report. Neurol Med Chir (Tokyo) 36:598–601

    Article  CAS  Google Scholar 

  3. Hung PC, Wang HS, Chou ML, Sun PC, Huang SC (1994) Intracranial meningiomas in childhood. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 35:495–501

    CAS  PubMed  Google Scholar 

  4. Ferrante L, Acqui M, Artico M, Mastronardi L, Rocchi G, Fortuna A (1989) Cerebral meningiomas in children. Childs Nerv Syst 5:83–86

    Article  CAS  Google Scholar 

  5. Erdincler P, Lena G, Sarioglu AC, Kuday C, Choux M (1998) Intracranial meningiomas in children: review of 29 cases. Surg Neurol 49:136–140; discussion 140-131

    Article  CAS  Google Scholar 

  6. Chidambaram B, Balasubramaniam V (1997) Meningioma without dural attachment in a child. Childs Nerv Syst 13:639–641

    Article  CAS  Google Scholar 

  7. Artico M, Ferrante L, Cervoni L, Colonnese C, Fortuna A (1995) Pediatric cystic meningioma: report of three cases. Childs Nerv Syst 11:137–140

    Article  CAS  Google Scholar 

  8. Ferrante L, Acqui M, Artico M, Mastronardi L, Fortuna A (1989) Paediatric intracranial meningiomas. Br J Neurosurg 3:189–196

    Article  CAS  Google Scholar 

  9. Liu X, Zhang Y, Zhang S, Tao C, Ju Y (2018) Intraparenchymal atypical meningioma in basal ganglia region in a child: case report and literature review. J Korean Neurosurg Soc 61:120–126

    Article  Google Scholar 

  10. Munjal S, Vats A, Kumar J, Srivastava A, Mehta VS (2016) Giant pediatric intraventricular meningioma: case report and review of literature. J Pediatr Neurosci 11:219–222

    Article  Google Scholar 

  11. Ravanpay AC, Barkley A, White-Dzuro GA, Cimino PJ, Gonzalez-Cuyar LF, Lockwood C, Halasz LM, Hisama FM, Ferreira M (2018) Giant pediatric rhabdoid meningioma associated with a germline BAP1 pathogenic variation: a rare clinical case. World Neurosurg 119:402–415

    Article  Google Scholar 

  12. Donovan DJ, Thavapalan V (2016) Pediatric meningeal tumors of the Sylvian fissure region without dural attachment: a series of three patients and review of the literature. Surg J (N Y) 2:e31–e36

    Google Scholar 

  13. Teo JG, Goh KY, Rosenblum MK, Muszynski CA, Epstein FJ (1998) Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Case report and literature review. Pediatr Neurosurg 28:27–30

    Article  CAS  Google Scholar 

  14. Karadereler S, Aker F, Berkman Z (2004) Intraparenchymal meningioma in a child. Case report and review of the literature. J Neurosurg 101:112–115

    PubMed  Google Scholar 

  15. Wada T, Suzuki M, Beppu T, Arai H, Yoshida Y, Ogawa A, Sasou S (2000) A case of subcortical meningioma. Acta Neurochir 142:209–213

    Article  CAS  Google Scholar 

  16. Silbergeld D, Berger M, Griffin B (1988) Sylvian fissure meningioma in a child: case report and review of the literature. Pediatr Neurosci 14:50–53

    Article  CAS  Google Scholar 

  17. Okamoto S, Handa H, Yamashita J, Tokuriki Y (1985) Deep Sylvian meningiomas. Surg Neurol 23:303–308

    Article  CAS  Google Scholar 

  18. Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE (2018) Salvage therapy outcomes for atypical meningioma. J Neuro-Oncol 138:425–433

    Article  Google Scholar 

  19. Harter PN, Braun Y, Plate KH (2017) Classification of meningiomas-advances and controversies. Chin Clin Oncol 6:S2

    Article  Google Scholar 

  20. Yilmaz A, Kizilay Z, Sair A, Avcil M, Ozkul A (2016) Spontaneous regression of an incidental spinal meningioma. Open Access Maced J Med Sci 4:128–130

    Article  Google Scholar 

  21. Hirota K, Fujita T, Akagawa H, Onda H, Kasuya H (2014) Spontaneous regression together with increased calcification of incidental meningioma. Surg Neurol Int 5:73

    Article  Google Scholar 

  22. Kotecha RS, Junckerstorff RC, Lee S, Cole CH, Gottardo NG (2011) Pediatric meningioma: current approaches and future direction. J Neuro-Oncol 104:1–10

    Article  Google Scholar 

  23. D’Ambrosio AL, Bruce JN (2003) Treatment of meningioma: an update. Curr Neurol Neurosci Rep 3:206–214

    Article  Google Scholar 

  24. Mehta N, Bhagwati S, Parulekar G (2009) Meningiomas in children: a study of 18 cases. J Pediatr Neurosci 4:61–65

    Article  Google Scholar 

  25. Lakhdar F, Arkha Y, El Ouahabi A, Melhaoui A, Rifi L, Derraz S, El Khamlichi A (2010) Intracranial meningioma in children: different from adult forms? A series of 21 cases. Neurochirurgie 56:309–314

    Article  CAS  Google Scholar 

  26. Liu Y, Li F, Zhu S, Liu M, Wu C (2008) Clinical features and treatment of meningiomas in children: report of 12 cases and literature review. Pediatr Neurosurg 44:112–117

    Article  Google Scholar 

  27. Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B (2009) Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir 151:239–244 discussion 244

    Article  CAS  Google Scholar 

  28. Amirjamshidi A, Mehrazin M, Abbassioun K (2000) Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature. Childs Nerv Syst 16:406–416

    Article  CAS  Google Scholar 

  29. Caroli E, Russillo M, Ferrante L (2006) Intracranial meningiomas in children: report of 27 new cases and critical analysis of 440 cases reported in the literature. J Child Neurol 21:31–36

    Article  Google Scholar 

  30. Alexiou GA, Mpairamidis E, Psarros A, Sfakianos G, Prodromou N (2008) Intracranial meningiomas in children: report of 8 cases. Pediatr Neurosurg 44:373–375

    Article  Google Scholar 

  31. Santos MV, Furlanetti L, Valera ET, Brassesco MS, Tone LG, de Oliveira RS (2012) Pediatric meningiomas: a single-center experience with 15 consecutive cases and review of the literature. Childs Nerv Syst 28:1887–1896

    Article  Google Scholar 

  32. Ravindranath K, Vasudevan MC, Pande A, Symss N (2013) Management of pediatric intracranial meningiomas: an analysis of 31 cases and review of literature. Childs Nerv Syst 29:573–582

    Article  Google Scholar 

  33. Li Z, Zhang Y, Wang E, Wang Z, Li W, Huang S, Li J (2012) Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. Childs Nerv Syst 28:2143–2151

    Article  Google Scholar 

  34. Li H, Zhao M, Wang S, Cao Y, Zhao J (2016) Prediction of pediatric meningioma recurrence by preoperative MRI assessment. Neurosurg Rev 39:663–669

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Neurosurgery, National Center for Child Health and Development, Tokyo, Japan

    Sukwoo Hong, Kenichi Usami, Daisuke Hirokawa & Hideki Ogiwara

  2. Setagaya-ku, Japan

    Hideki Ogiwara

Authors
  1. Sukwoo Hong
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  2. Kenichi Usami
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  3. Daisuke Hirokawa
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  4. Hideki Ogiwara
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Correspondence to Hideki Ogiwara.

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Hong, S., Usami, K., Hirokawa, D. et al. Pediatric meningiomas: a report of 5 cases and review of literature. Childs Nerv Syst 35, 2219–2225 (2019). https://doi.org/10.1007/s00381-019-04142-y

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  • DOI: https://doi.org/10.1007/s00381-019-04142-y

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