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Medulloblastoma in association with sacral agenesis; a case report

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Abstract

Medulloblastoma is a congenital brain tumor which can be associated with different congenital anomalies. However, coincidence of cerebellar medulloblastoma with sacral agenesis has not been reported so far. A variety of genetic and/or environmental predisposing factors have been proposed for both diseases. Herein, an unprecedented coincidence of these two conditions is presented. A neonate was born with lumbosacral agenesis, paraplegia, and atrophic legs, and he developed medulloblastoma with three ventricular hydrocephalus 3 years later. Different aspects regarding the embryology and etiology of both ailments are discussed, assuming the possibility that the same genetic and/or environmental risk factors may have played a part in both conditions.

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Authors and Affiliations

  1. Department of Neurosurgery, Children’s Hospital Medical Center, Tehran University of Medical Sciences, No 62, Qarib St., Keshavarz Blvd, Tehran, 1419733151, Iran

    Zahra Ebrahim Soltani, Zohreh Habibi & Farideh Nejat

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  1. Zahra Ebrahim Soltani
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  2. Zohreh Habibi
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  3. Farideh Nejat
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Correspondence to Zohreh Habibi.

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Soltani, Z.E., Habibi, Z. & Nejat, F. Medulloblastoma in association with sacral agenesis; a case report. Childs Nerv Syst 34, 1263–1266 (2018). https://doi.org/10.1007/s00381-018-3737-6

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  • DOI: https://doi.org/10.1007/s00381-018-3737-6

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