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Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition

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Abstract

Background

Hypertrophic olivary degeneration (HOD) is a rare transsynaptic form of degeneration occurring after injury to the dentato-rubro-olivary pathway (“Guillain-Mollaret triangle”). The majority of studies have described HOD resulting from posterior fossa (PF) hemorrhage or infarction. HOD in patients undergoing PF surgery has not been well characterized. These lesions are rare and symptomatic children with HOD are even more uncommon. The purpose of this study was to evaluate HOD that develops after PF operations in children.

Materials and methods

A literature review was carried out describing 37 pediatric cases of HOD in 13 articles. In addition, two new cases of our own experience were included.

Conclusions

HOD is a rare complication related after PF tumors surgery and symptoms may be misdiagnosed with pediatric cerebellar mutism syndrome. Children with HOD usually do not develop palatal tremor but ataxia is common.

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Authors and Affiliations

  1. Division of Pediatric Neurosurgery of the Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil

    Matheus Fernando Manzolli Ballestero, Dinark Conceição Viana, Thiago Lyrio Teixeira, Marcelo Volpon Santos & Ricardo Santos de Oliveira

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  1. Matheus Fernando Manzolli Ballestero
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Correspondence to Matheus Fernando Manzolli Ballestero.

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There was no financial support nor industry affiliations involved in this work. None of the authors has any personal or institutional financial interest in drugs, materials, or devices.

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Ballestero, M.F.M., Viana, D.C., Teixeira, T.L. et al. Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition. Childs Nerv Syst 34, 409–415 (2018). https://doi.org/10.1007/s00381-017-3705-6

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