Abstract
Purpose
Nuclear medicine studies have previously been utilized to assess for blockage of cerebrospinal fluid (CSF) flow prior to intraventricular chemotherapy infusions. To assess CSF flow without nuclear medicine studies, we obtained cine phase-contrast MRI sequences that assess CSF flow from the fourth ventricle down to the sacrum.
Methods
In three clinical trials, 18 patients with recurrent malignant posterior fossa tumors underwent implantation of a ventricular access device (VAD) into the fourth ventricle, either with or without simultaneous tumor resection. Prior to infusing therapeutic agents into the VAD, cine MRI phase-contrast CSF flow sequences of the brain and total spine were performed. Velocity encoding (VENC) of 5 and 10 cm/s was used to confirm CSF flow from the fourth ventricular outlets to the cervical, thoracic, and lumbar spine. Qualitative CSF flow was characterized by neuroradiologists as present or absent.
Results
All 18 patients demonstrated CSF flow from the outlets of the fourth ventricle down to the sacrum with no evidence of obstruction. One of these patients, after disease progression, subsequently showed obstruction of CSF flow. No patient required a nuclear medicine study to assess CSF flow prior to initiation of infusions. Fourteen patients have received infusions to date, and none has had neurological toxicity.
Conclusions
CSF flow including the fourth ventricle and the total spine can be assessed noninvasively with phase-contrast MRI sequences. Advantages over nuclear medicine studies include avoiding both an invasive procedure and radiation exposure.
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Funding
This study has been supported by funding from Texas 4000 for Cancer, Houston’s Men of Distinction Award (Dr. Sandberg), and funds provided by the Division of Pediatrics at the University of Texas MD Anderson Cancer Center.
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All three studies were performed after obtaining institutional review board (IRB) approval and in accordance with the ethical standards as outlined in the 1964 Declaration of Helsinki and its later amendments.
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On behalf of all authors, the corresponding author states that there is no conflict of interest.
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Patel, R.P., Sitton, C.W., Ketonen, L.M. et al. Phase-contrast cerebrospinal fluid flow magnetic resonance imaging in qualitative evaluation of patency of CSF flow pathways prior to infusion of chemotherapeutic and other agents into the fourth ventricle. Childs Nerv Syst 34, 481–486 (2018). https://doi.org/10.1007/s00381-017-3669-6
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DOI: https://doi.org/10.1007/s00381-017-3669-6