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A retrospective review of 34 cases of pediatric pituitary adenoma

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Abstract

Purpose

The purpose of this paper is to study invasiveness, tumor features and clinical symptoms of pediatric pituitary adenoma, and to discuss some inconclusive results in prior studies.

Methods

We retrospectively reviewed 34 cases of children (<20 year-old) who were pathologically diagnosed with pituitary adenoma and surgically treated from 2010 to 2017. Data of general information, clinical symptoms, invasive behaviors, surgery approaches, and tumor features were collected and analyzed.

Results

Sixteen boys and 18 girls aged from 12 to 19 years old were included. Prolactinoma was most suffered, followed by GH-, none- and ACTH-secreting pituitary adenoma. Invasive behaviors were observed frequently and suprasellar extensions were most found. Macroadenoma account 70% of all cases. Meanwhile, unlike prior studies, a significant raise of incidence on invasive tumor and pituitary adenoma apoplexy were observed. Craniotomy and transsphenoidal surgery were both applied with zero mortality. Nine cases occurred with transient hypopituitarism and diabetes insipidus. Three cases of tumor recurrence received secondary surgery or radiotherapy.

Conclusions

Invasive behaviors were more frequent than previous prediction. Craniotomy is worth considering for total tumor removal. Pituitary adenoma apoplexy needs further studies since its different features between children and adults in present study. Specialized care and teamwork of neurosurgeons, pediatricians, and endocrinologists are important.

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Author information

Author notes

  1. Nannan Zhang and Peizhi Zhou contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Neurosurgery, West China Hospital, Sichuan University, 37th Guoxue Alley, Chengdu, China

    Nannan Zhang, Peizhi Zhou & Shu Jiang

  2. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China

    Yu Meng

  3. Department of Neurosurgery, Deyang People’s Hospital, Deyang, China

    Feng Ye

Authors
  1. Nannan Zhang
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  2. Peizhi Zhou
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  3. Yu Meng
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  4. Feng Ye
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  5. Shu Jiang
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Corresponding author

Correspondence to Shu Jiang.

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Funding

This study was funded by the Department of Science and Technology of Sichuan Province (2016SZ0015).

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of West China Hospital, Sichuan University, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Zhang, N., Zhou, P., Meng, Y. et al. A retrospective review of 34 cases of pediatric pituitary adenoma. Childs Nerv Syst 33, 1961–1967 (2017). https://doi.org/10.1007/s00381-017-3538-3

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  • DOI: https://doi.org/10.1007/s00381-017-3538-3

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