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Hodgkin’s lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature

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An Erratum to this article was published on 27 April 2017

Abstract

Paraneoplastic cerebellar degeneration (PCD) can occur severely and appear as subacute cerebellar syndrome. PCD may be associated with small cell lung cancer, adenocarcinoma, breast cancer, ovarian carcinoma, and Hodgkin’s lymphoma. An 11-year-old male was admitted with acute cerebellar ataxia, dysarthria, and diplopia. Mediastinal conglomerated lymph nodes were depicted in a chest computed tomography (CT) examination, and diagnosis of stage IV Hodgkin’s lymphoma was obtained after a lymph node biopsy. The antibodies against Purkinje cells (anti-Tr antibody) were positive immunohistochemically. Thus, paraneoplastic cerebellar degeneration depending on Hodgkin’s disease was diagnosed. Despite the completion of chemotherapy, neurological recovery was not observed in the patient and plasmapheresis with immunoadsorption, and intravenous immunoglobulin (IVIG) was performed. Truncal ataxia, gait disturbance, and tremors decreased. Consequently, we thought that plasmapheresis with the immunoadsorption method and IVIG therapy might be a treatment option for cerebellar ataxia caused by a mechanism of immune ancestry.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pediatric Neurology, Inonu University, Malatya, Turkey

    Serdal Gungor, Betul Kilic & Mujgan Arslan

  2. Faculty of Medicine, Department of Pediatric Hematology, Inonu University, Malatya, Turkey

    Unsal Ozgen

  3. University of Barcelona, Catalan Institution of Research and Advanced Studies (ICREA) and Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain

    Josep Dalmau

Authors
  1. Serdal Gungor
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  2. Betul Kilic
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  3. Mujgan Arslan
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  4. Unsal Ozgen
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  5. Josep Dalmau
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Correspondence to Betul Kilic.

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An erratum to this article is available at http://dx.doi.org/10.1007/s00381-017-3396-z.

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Gungor, S., Kilic, B., Arslan, M. et al. Hodgkin’s lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature. Childs Nerv Syst 33, 509–512 (2017). https://doi.org/10.1007/s00381-016-3284-y

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  • DOI: https://doi.org/10.1007/s00381-016-3284-y

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