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Association between paroxysmal or persistent atrial fibrillation and hyperuricemia in patients who underwent coronary computed tomography angiography: from the FU-CCTA-AF Registry

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Abstract

Background

Hyperuricemia (HU) and hypertension (HTN) contribute to atherosclerotic cardiovascular disease, and both are also involved in the onset and development of atrial fibrillation (AF).

Objective

In the present study, we investigated the association between risk factors for atherosclerosis [including HU, HTN, blood pressure and serum uric acid (UA) levels] and paroxysmal atrial fibrillation (Paro-AF) or persistent atrial fibrillation (Pers-AF) in patients who underwent coronary computed tomography angiography (CCTA).

Methods

We enrolled 263 patients from the Fukuoka University-CCTA-AF (FU-CCTA-AF Registry) who underwent CCTA prior to AF ablation therapy. AF was classified as either Paro-AF (≤ 7 days) or Pers-AF (> 7 days). HU was diagnosed by a serum UA level > 7.0 mg/dl, and coronary artery disease (CAD) was diagnosed when CCTA results showed ≥ 50% significant coronary artery stenosis. The number of significantly diseased coronary artery vessels (VD), the Gensini score and the coronary artery calcification score (CACS) were measured. Left atrial morphology was also evaluated.

Results

Diastolic blood pressure and HbA1c in the Pers-AF group were significantly higher than those in the Paro-AF group. The Pers-AF group showed a significantly higher prevalence of HU and higher UA levels than the Paro-AF group. In a multivariate logistic regression analysis, HU was an independent associated factor to Pers-AF (odds ratio: 2.023, 95% confidence interval: 1.055–3.881, p = 0.034), while HTN was not.

Conclusion

In patients with AF, HU is associated with Pers-AF.

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Data availability

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.

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Acknowledgements

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Funding

The authors declare that no funding, grant, or other support was received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka, 814-0180, Japan

    Masashi Mikagi, Yuhei Shiga & Shin-ichiro Miura

  2. Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan

    Masashi Mikagi, Kohei Tashiro, Tomo Komaki, Tetsuro Tachibana, Sara Higashi, Yuto Kawahira, Yasunori Suematsu, Akihito Ideishi, Masahiro Ogawa & Shin-ichiro Miura

  3. Department of Laboratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan

    Masahiro Ogawa & Shin-ichiro Miura

  4. Department of Internal Medicine, Fukuoka University Nishijin Hospital, Fukuoka, Japan

    Shin-ichiro Miura

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  1. Masashi Mikagi
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  2. Kohei Tashiro
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Correspondence to Shin-ichiro Miura.

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Mikagi, M., Tashiro, K., Komaki, T. et al. Association between paroxysmal or persistent atrial fibrillation and hyperuricemia in patients who underwent coronary computed tomography angiography: from the FU-CCTA-AF Registry. Heart Vessels 38, 1451–1458 (2023). https://doi.org/10.1007/s00380-023-02299-w

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