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Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1–7) concentration in patients with acute heart failure patients requiring emergency hospitalization

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Abstract

The existence of a new cascade, angiotensin-converting enzyme (ACE) 2/angiotensin (Ang)-(1–7)/Mas receptor axis, has been recently established in the renin–angiotensin system. However, the dynamics of this cascade under various pathological conditions in clinical settings is still unclear. Forty-nine patients who underwent emergency hospitalization because of acute heart failure (AHF) consented to participate in this study. Thirty-eight healthy volunteers served as controls. Serum ACE activity, ACE2, Ang-(1–7) concentration, plasma Ang II, aldosterone concentration, and plasma renin activity (PRA) were measured at the acute stage. We conducted a comparative study between patients with AHF and healthy volunteers. Patients with AHF showed lower serum ACE activity and plasma aldosterone concentration than healthy volunteers (12.3 vs. 15.1 IU/L, respectively; P = 0.01, 75.6 vs. 125.3 pg/mL, respectively; P = 0.000); there were no differences between the two groups in PRA and plasma Ang II concentration. Patients with AHF had a higher serum ACE2 concentration than healthy volunteers (7.9 vs. 4.8 ng/mL, respectively; P = 0.002), but their serum Ang-(1–7) concentration was significantly lower (2.4 vs 3.1 ng/mL, respectively; P = 0.005). Patients with AHF had a higher serum ACE2 concentration, lower serum Ang-(1–7) concentration, and lower serum ACE activity and plasma aldosterone concentrations than healthy volunteers, whereas PRA and plasma Ang II concentration were the same.

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Acknowledgments

This manuscript was supported in part by Grants-in-Aid (24591074 to T.I.) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan

    Shinji Hisatake, Shunsuke Kiuchi, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi & Takanori Ikeda

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  1. Shinji Hisatake
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  2. Shunsuke Kiuchi
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  3. Takayuki Kabuki
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  4. Takashi Oka
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  5. Shintaro Dobashi
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  6. Takanori Ikeda
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Correspondence to Shinji Hisatake.

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Hisatake, S., Kiuchi, S., Kabuki, T. et al. Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1–7) concentration in patients with acute heart failure patients requiring emergency hospitalization. Heart Vessels 32, 303–308 (2017). https://doi.org/10.1007/s00380-016-0877-z

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  • DOI: https://doi.org/10.1007/s00380-016-0877-z

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