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Comparison of clinical characteristics in patients with Takayasu arteritis with and without concomitant tuberculosis

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Abstract

Because of frequent tuberculosis in patients with Takayasu arteritis (TA), a possible relationship between TA and tuberculosis has been proposed. However, there are no studies to date that have examined clinical manifestations in patients diagnosed with TA with or without tuberculosis. Two hundred sixty-seven patients were diagnosed with TA according to the 1990 American College of Rheumatology criteria between September 1994 and April 2014. Patients with TA were classified into groups with or without tuberculosis. Among the 267 patients with TA studied, 47 patients (17.7 %) who had a history of previous treatment of tuberculosis (34 patients), concurrent diagnosis of tuberculosis with TA (10 patients), or diagnosis of tuberculosis during the follow-up period for TA (3 patients) were included in the group with tuberculosis. The group with tuberculosis comprised of 33 patients (70.2 %) with pulmonary tuberculosis, 12 patients (25.5 %) with tuberculous lymphadenitis, and 2 patients (4.3 %) with tuberculosis of the skin and colon, respectively. Comorbid disease and patients’ signs and symptoms were not significantly different between TA patients with and without tuberculosis. Additionally, the site of disease involvement in angiographic findings and distribution of angiographic type were similar between the two groups. In conclusion, tuberculosis including tuberculous lymphadenitis was frequently observed in patients with TA. Clinical features and angiographic findings in TA were not different according to the presence or absence of concomitant tuberculosis.

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References

  1. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS (1994) Takayasu arteritis. Ann Intern Med 120:919–929

    Article  CAS  PubMed  Google Scholar 

  2. de Souza AW, de Carvalho JF (2014) Diagnostic and classification criteria of Takayasu arteritis. J Autoimmun 48–49:79–83

    Article  PubMed  Google Scholar 

  3. Funada A, Kanzaki H, Nagano N, Sugano Y, Ohara T, Hasegawa T, Ishibashi-Ueda H, Kitakaze M, Anzai T (2014) Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu’s arteritis. Heart Vessels. doi:10.1007/s00380-014-0501-z

    Google Scholar 

  4. Vaideeswar P, Deshpande JR (2013) Pathology of Takayasu arteritis: a brief review. Ann Pediatr Cardiol 6:52–58

    Article  PubMed  PubMed Central  Google Scholar 

  5. Moore JW, Reardon MJ, Cooley DA, Vargo TA (1985) Severe Takayasu’s arteritis of the pulmonary arteries: report of a case with successful surgical treatment. J Am Coll Cardiol 5:369–373

    Article  CAS  PubMed  Google Scholar 

  6. Yotsuyanagi H, Chikatsu N, Kaneko Y, Kurokawa K (1995) Takayasu’s arteritis in prepulseless stage manifesting lymph node swelling and hepatosplenomegaly. Intern Med 34:455–459

    Article  CAS  PubMed  Google Scholar 

  7. Pantell RH, Goodman BW Jr (1981) Takayasu’s arteritis: the relationship with tuberculosis. Pediatrics 67:84–88

    CAS  PubMed  Google Scholar 

  8. Clemente G, Hilario MO, Lederman H, Silva CA, Sallum AM, Campos LM, Sacchetti S, dos Santos MC, Ferriani VP, Sztajnbok F, Gasparello R, Knupp Oliveira S, Lessa M, Bica B, Cavalcanti A, Robazzi T, Bandeira M, Terreri MT (2014) Takayasu arteritis in a Brazilian multicenter study: children with a longer diagnosis delay than adolescents. Clin Exp Rheumatol 32:S128–S133

    PubMed  Google Scholar 

  9. Karageorgaki ZT, Bertsias GK, Mavragani CP, Kritikos HD, Spyropoulou-Vlachou M, Drosos AA, Boumpas DT, Moutsopoulos HM (2009) Takayasu arteritis: epidemiological, clinical, and immunogenetic features in Greece. Clin Exp Rheumatol 27:S33–S39

    CAS  PubMed  Google Scholar 

  10. Soto ME, Espinola N, Flores-Suarez LF, Reyes PA (2008) Takayasu arteritis: clinical features in 110 Mexican Mestizo patients and cardiovascular impact on survival and prognosis. Clin Exp Rheumatol 26:S9–15

    CAS  PubMed  Google Scholar 

  11. Soto ME, Del Carmen Avila-Casado M, Huesca-Gomez C, Alarcon GV, Castrejon V, Soto V, Hernandez S, Espinola-Zavaleta N, Vallejo M, Reyes PA, Gamboa R (2012) Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovis in the aortic tissue of patients with Takayasu’s arteritis. BMC Infect Dis 12:194

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kumar Chauhan S, Kumar Tripathy N, Sinha N, Singh M, Nityanand S (2004) Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu’s arteritis. Clin Exp Immunol 138:547–553

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Aggarwal A, Chag M, Sinha N, Naik S (1996) Takayasu’s arteritis: role of Mycobacterium tuberculosis and its 65 kDa heat shock protein. Int J Cardiol 55:49–55

    Article  CAS  PubMed  Google Scholar 

  14. Hernandez-Pando R, Reyes P, Espitia C, Wang Y, Rook G, Mancilla R (1994) Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu’s arteritis. J Rheumatol 21:1870–1876

    CAS  PubMed  Google Scholar 

  15. van Timmeren MM, Heeringa P, Kallenberg CG (2014) Infectious triggers for vasculitis. Curr Opin Rheumatol 26:416–423

    Article  PubMed  Google Scholar 

  16. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW Jr (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134

    Article  CAS  PubMed  Google Scholar 

  17. Hata A, Noda M, Moriwaki R, Numano F (1996) Angiographic findings of Takayasu arteritis: new classification. Int J Cardiol 54(Suppl):S155–S163

    Article  PubMed  Google Scholar 

  18. Choi CJ, Seo M, Choi WS, Kim KS, Youn SA, Lindsey T, Choi YJ, Kim CM (2013) Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults in Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2010. J Clin Endocrinol Metab 98:1703–1710

    Article  CAS  PubMed  Google Scholar 

  19. Lee BR, Kim YI, Kim S, Lee HS, Yoon SH, Yu JY, Ban HJ, Kwon YS, Oh IJ, Kim KS, Kim YC, Lim SC (2014) Prevalence of chronic sputum and associated factors in Korean adults. J Korean Med Sci 29:825–830

    Article  PubMed  PubMed Central  Google Scholar 

  20. Lee SW, Kim YS, Kim DS, Oh YM, Lee SD (2011) The risk of obstructive lung disease by previous pulmonary tuberculosis in a country with intermediate burden of tuberculosis. J Korean Med Sci 26:268–273

    Article  PubMed  PubMed Central  Google Scholar 

  21. Karadag O, Aksu K, Sahin A, Zihni FY, Sener B, Inanc N, Kalyoncu U, Aydin SZ, Ascioglu S, Ocakci PT, Bilgen SA, Keser G, Inal V, Direskeneli H, Calguneri M, Ertenli I, Kiraz S (2010) Assessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test. Rheumatol Int 30:1483–1487

    Article  PubMed  Google Scholar 

  22. Peto HM, Pratt RH, Harrington TA, LoBue PA, Armstrong LR (2009) Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin Infect Dis 49:1350–1357

    Article  PubMed  Google Scholar 

  23. Handa U, Mundi I, Mohan S (2012) Nodal tuberculosis revisited: a review. J Infect Dev Ctries 6:6–12

    Article  PubMed  Google Scholar 

  24. Mohapatra PR, Janmeja AK (2009) Tuberculous lymphadenitis. J Assoc Physicians India 57:585–590

    PubMed  Google Scholar 

  25. Korea Centers for Disease Control and Prevention (2011) Annual report on the notified tuberculosis in Korea [Internet]. Korea Centers for Disease Control and Prevention, Korea; 2012 [cited 2014 Jul 9]. http://tbzero.cdc.go.kr/tbzero/board/boardView.do

  26. Lupi-Herrera E, Sanchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (1977) Takayasu’s arteritis. Clinical study of 107 cases. Am Heart J 93:94–103

    Article  CAS  PubMed  Google Scholar 

  27. Al-Aghbari K, Al-Motarreb A, Askar F (2010) Takayasu’s Arteritis Associated with Tuberculosis in a Young Yemeni Woman. Heart Views 11:117–120

    Article  PubMed  PubMed Central  Google Scholar 

  28. Rose AG, Sinclair-Smith CC (1980) Takayasu’s arteritis. A study of 16 autopsy cases. Arch Pathol Lab Med 104:231–237

    CAS  PubMed  Google Scholar 

  29. Bacon P, Sivakumar R (2005) Takayasu Aortoarteritis. Rheumatologia 21:127–129

    Google Scholar 

  30. Nasu T (1963) Pathology of pulseless disease. A systematic study and critical review of twenty-one autopsy cases reported in Japan. Angiology 14:225–242

    Article  CAS  PubMed  Google Scholar 

  31. Miller DV, Maleszewski JJ (2011) The pathology of large-vessel vasculitides. Clin Exp Rheumatol 29:S92–S98

    PubMed  Google Scholar 

  32. Asano S (2012) Granulomatous lymphadenitis. J Clin Exp Hematop 52:1–16

    Article  PubMed  Google Scholar 

  33. Seedat YK (1988) Primary arteritis of the aorta and its branches. S Afr Med J 74:71–73

    CAS  PubMed  Google Scholar 

  34. Hoffman GS, Ahmed AE (1998) Surrogate markers of disease activity in patients with Takayasu arteritis. A preliminary report from The International Network for the Study of the Systemic Vasculitides (INSSYS). Int J Cardiol 66(Suppl 1):S191–S194 (discussion S195)

  35. Matsumura T, Amiya E, Tamura N, Maejima Y, Komuro I, Isobe M (2015) A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity. Heart Vessels. doi:10.1007/s00380-015-0661-5

    Google Scholar 

  36. Arnaud L, Haroche J, Malek Z, Archambaud F, Gambotti L, Grimon G, Kas A, Costedoat-Chalumeau N, Cacoub P, Toledano D, Cluzel P, Piette JC, Amoura Z (2009) Is (18)F-fluorodeoxyglucose positron emission tomography scanning a reliable way to assess disease activity in Takayasu arteritis? Arthritis Rheum 60:1193–1200

    Article  PubMed  Google Scholar 

  37. Aydin SZ, Yilmaz N, Akar S, Aksu K, Kamali S, Yucel E, Karadag O, Bicakcigil M, Ozer H, Kiraz S, Onen F, Inanc M, Keser G, Akkoc N, Direskeneli H (2010) Assessment of disease activity and progression in Takayasu’s arteritis with Disease Extent Index-Takayasu. Rheumatology (Oxford) 49:1889–1893

    Article  PubMed  Google Scholar 

  38. Terao C, Yoshifuji H, Mimori T (2014) Recent advances in Takayasu arteritis. Int J Rheum Dis 17:238–247

    Article  CAS  PubMed  Google Scholar 

  39. Schultz DR, Arnold PI (1993) Heat shock (stress) proteins and autoimmunity in rheumatic diseases. Semin Arthritis Rheum 22:357–374

    Article  CAS  PubMed  Google Scholar 

  40. Mwipatayi BP, Jeffery PC, Beningfield SJ, Matley PJ, Naidoo NG, Kalla AA, Kahn D (2005) Takayasu arteritis: clinical features and management: report of 272 cases. ANZ J Surg 75:110–117

    Article  PubMed  Google Scholar 

  41. Hahn D, Thomson PD, Kala U, Beale PG, Levin SE (1998) A review of Takayasu’s arteritis in children in Gauteng, South Africa. Pediatr Nephrol 12:668–675

    Article  CAS  PubMed  Google Scholar 

  42. Robles M, Reyes PA (1994) Takayasu’s arteritis in Mexico: a clinical review of 44 consecutive cases. Clin Exp Rheumatol 12:381–388

    CAS  PubMed  Google Scholar 

  43. Chae MJ, Yu CW, Lee SY, Jang DH, Hyun JY, Jeong SJ, Kim MH (2013) Takayasu's disease in a patient with ulcerative colitis. Korean Circ J 43:135–138

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This study was supported by a grant through the Samsung Medical Center Clinical Research Development Program (No. CRS110-04-1).

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea

    A. Young Lim, Ga Yeon Lee, Shin Yi Jang, Hye Bin Gwag, Seung Hyuk Choi, Eun-Seok Jeon & Duk-Kyung Kim

  2. Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Hoon-Suk Cha

  3. Department of Thoracic and Cardiovascular Surgery, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Kiick Sung

  4. Division of Vascular Surgery, Department of Surgery, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Young-Wook Kim

  5. Department of Radiology and Center for Imaging Science, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Sung Mok Kim & Yeon Hyeon Choe

  6. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Won-Jung Koh

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  1. A. Young Lim
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Correspondence to Duk-Kyung Kim.

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Lim, A.Y., Lee, G.Y., Jang, S.Y. et al. Comparison of clinical characteristics in patients with Takayasu arteritis with and without concomitant tuberculosis. Heart Vessels 31, 1277–1284 (2016). https://doi.org/10.1007/s00380-015-0731-8

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  • DOI: https://doi.org/10.1007/s00380-015-0731-8

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