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Neointimal coverage of zotarolimus-eluting stent at 1, 2, and 3 months’ follow-up: an optical coherence tomography study

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Abstract

Incomplete neointimal coverage and malapposed struts after stenting are associated with increased risk of stent thrombosis. We aimed to evaluate neointimal coverage early after Resolute zotarolimus-eluting stent (R-ZES) implantation using optical coherence tomography (OCT). A total of 20 patients with de novo native coronary lesions with R-ZES were enrolled. Among these patients, 20 stented lesions in 19 patients were evaluated at 1, 2, and 3 months after R-ZES implantation. The strut apposition and neointimal coverage were evaluated by OCT. Neointimal hyperplasia (NIH) thickness and percentage of covered struts and the proportion of incompletely apposed struts were measured at 1-mm intervals. The mean percentages of covered stent struts were over 85 % within 3 months (88.4 ± 6.3 % at 1 month, 95.5 ± 5.5 % at 2 months, 93.6 ± 3.5 % at 3 months). The percentages of incompletely apposed struts were not significantly different among the groups (4.4 ± 4.2 % at 1 month, 1.9 ± 1.9 % at 2 months, 3.1 ± 2.2 % at 3 months, p = 0.51). Mean NIH thickness (38.9 ± 8.1 μm at 1 month, 70.6 ± 18.8 μm at 2 months, 54.1 ± 5.9 at 3 months, p = 0.0016) was thickest in the 2 months group. Most of all OCT findings within 2 months demonstrated neointimal coverage with low signal intensity. The neointimal coverage of ZES-R was over 85 % within 3 months. These data may support shorter requirement of dual antiplatelet therapy duration with R-ZES.

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Acknowledgments

The authors have nothing to disclose and are solely responsible for the design and conduct of this study, drafting and editing of the manuscript and its final contents.

Conflict of interest

This research received no grant from any funding agency in the public, commercial or not-for-profit sectors. Dr. Junya Ako received speaking honorarium from Medtronic. Other authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan

    Takehiro Hashikata, Taiki Tojo, Sayaka Namba, Lisa Kitasato, Takuya Hashimoto, Ryo Kameda, Takao Shimohama, Minako Yamaoka-Tojo & Junya Ako

  2. Department of Rehabilitation, Kitasato University School of Allied Health Sciences, Sagamihara, Japan

    Minako Yamaoka-Tojo

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  1. Takehiro Hashikata
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  2. Taiki Tojo
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  3. Sayaka Namba
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  4. Lisa Kitasato
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  5. Takuya Hashimoto
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  8. Minako Yamaoka-Tojo
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  9. Junya Ako
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Correspondence to Takehiro Hashikata.

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Hashikata, T., Tojo, T., Namba, S. et al. Neointimal coverage of zotarolimus-eluting stent at 1, 2, and 3 months’ follow-up: an optical coherence tomography study. Heart Vessels 31, 206–211 (2016). https://doi.org/10.1007/s00380-014-0598-0

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