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Association between hypertension and 24-h urine composition in adults without urolithiasis in China

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Abstract

Purpose

To explore the association between hypertension and 24-h urine composition in adults without urolithiasis in China.

Materials and methods

Blood test and 24-h urine analysis were performed on 958 non-stone formers in six cities to select eligible participants. Eligible participants were divided into hypertension group and non-hypertension group according to WHO guidelines. The 24-h urine compositions between two groups were compared using univariate and multivariate logistic regressions.

Results

A total of 584 adults without urolithiasis were included in this analysis. Compared with non-hypertension group, hypertension group had significantly older age, higher BMI, higher prevalence of diabetes mellitus and higher levels of total cholesterol and LDL, but lower eCCr value, lower levels of serum creatinine and serum sodium (all P value < 0.05). In univariable comparisons, hypertension patients had significantly higher level of urine potassium (mean difference [MD] = − 3.89 mmol, 95% confidence interval [CI] − 7.37 to − 0.42, P = 0.014) but lower levels of urine creatinine (MD = 0.80 mmol, 95% CI 0.21–1.39, P = 0.004) and pH (MD = 0.12, 95% CI − 0.01 to 0.25, P = 0.033) than non-hypertension adults. However, no significant difference was found in all 24-h urinary components between two groups (all P value > 0.05) in multivariate Logistic regression analyses.

Conclusions

Our study demonstrated that hypertension did not independently influence the 24-h urine composition in adults without urolithiasis in China; however, we cannot make such an arbitrary conclusion that hypertension was not a risk factor for urolithiasis.

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Acknowledgements

This study was financed by Grants from the Natural Science Foundation of Guangdong Province (No. 2017A030310547), China Postdoctoral Science Foundation (Nos. 2018T110859 and 2017M612636), National Natural Science Foundation of China (Nos. 81802821 and 81670643), the Collaborative Innovation Project of Guangzhou Education Bureau (No. 1201620011) the Guangzhou Science Technology and Innovation Commission (Nos. 201604020001 and 201704020193), and the Science and Technology Planning Project of Guangdong Province (No. 2017B030314108).

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Author notes

  1. Tuo Deng and Zanlin Mai contribute equally to this work.

Authors and Affiliations

  1. Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road 1#, Haizhu District, Guangzhou, 510230, Guangdong, China

    Tuo Deng, Zanlin Mai, Xiaolu Duan, Zhijian Zhao, Wei Zhu, Chao Cai, Wenqi Wu & Guohua Zeng

  2. Guangzhou Institute of Urology, Guangzhou, China

    Tuo Deng, Zanlin Mai, Xiaolu Duan, Zhijian Zhao, Wei Zhu, Chao Cai, Wenqi Wu & Guohua Zeng

  3. Guangdong Key Laboratory of Urology, Guangdong, China

    Tuo Deng, Zanlin Mai, Xiaolu Duan, Zhijian Zhao, Wei Zhu, Chao Cai, Wenqi Wu & Guohua Zeng

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  1. Tuo Deng
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  2. Zanlin Mai
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Contributions

TD: project development, data collection, data analysis, and manuscript writing; ZM, XD, ZZ, WZ and CC: data collection and manuscript editing; WW: project supervision and manuscript editing; GZ: project development, project supervision and manuscript editing.

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Correspondence to Guohua Zeng.

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This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University, China. Detailed information could be found in supplementary materials.

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Deng, T., Mai, Z., Duan, X. et al. Association between hypertension and 24-h urine composition in adults without urolithiasis in China. World J Urol 39, 589–595 (2021). https://doi.org/10.1007/s00345-020-03189-w

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  • DOI: https://doi.org/10.1007/s00345-020-03189-w

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