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The importance of targeting intracrinology in prostate cancer management

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Abstract

Accumulating evidence has shown that intracrinology in prostate cancer (PCa) has a pivotal role in survival of cancer cell. PCa cells are able to produce androgens from different androgen precursors, such as dehydroepiandrosterone, thereby maintaining androgen receptor signaling. Several drugs have been developed that target intracrinology, some of which are now being used as standard treatment for the so-called castrate-resistant prostate cancer (CRPC) patients. Recently, the US FDA approval has changed the indication of drugs targeting intracrinology, e.g., abiraterone and enzalutamide where it evolved from post-chemotherapy CRPC to hormone-naive metastatic PCa cases. This approval raises question whether those drugs can also be used as the first-line treatment in localized stage PCa cases. In addition, development of additional drugs targeting major components of intracrinology is ongoing. Application of these new drugs and administration of combinations of existing drugs will ultimately lead to an increase in the efficacy of such treatments as well as to reduce the toxicity of the therapy and to prevent the risk of resistance.

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Ciptomangunkusumo Hospital, University of Indonesia, Jalan Diponegoro No. 71, Central Jakarta, Jakarta, 10430, Indonesia

    Agus Rizal A. H. Hamid, William Tendi, Saras Serani Sesari, Chaidir A. Mochtar & Rainy Umbas

  2. Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Gerald Verhaegh & Jack A. Schalken

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  1. Agus Rizal A. H. Hamid
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  2. William Tendi
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  3. Saras Serani Sesari
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  4. Chaidir A. Mochtar
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Correspondence to Agus Rizal A. H. Hamid.

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Hamid, A.R.A.H., Tendi, W., Sesari, S.S. et al. The importance of targeting intracrinology in prostate cancer management. World J Urol 37, 751–757 (2019). https://doi.org/10.1007/s00345-018-2529-7

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  • DOI: https://doi.org/10.1007/s00345-018-2529-7

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