Abstract
Purpose
To investigate the inhibitory effects of electrical stimulation of sacral dorsal root ganglion (DRG) on bladder activity under non-nociceptive and nociceptive bladder conditions in cats.
Materials and methods
12 cats were divided into non-nociceptive and nociceptive groups. Saline was used to distend the bladder and induce non-nociceptive bladder activity, while acetic acid (AA, 0.25%) was used to induce nociceptive bladder overactivity, S1 or S2 DRG stimulation was applied via a pair of hook electrodes placed in the right S1 and S2 DRG.
Results
In both non-nociceptive and nociceptive groups, stimulation at 3 and 5 Hz significantly increased bladder capacity (BC) and no significantly different between the two frequencies. In non-nociceptive group, S1 DRG stimulation at 3 Hz was as effective (increasing BC to 139.7 ± 5.6 and 166.9 ± 12.21% of control at 1T and 3/2T, respectively) as S2 DRG stimulation (increases BC to 129.2 ± 5.6 and 160.5 ± 13.3% of control). In nociceptive group, AA reduced the BC to 62.6 ± 11.7% of saline control. S1 DRG stimulation at 3 Hz was also as effective (increasing BC to 54.9 ± 5.5 and 61.9 ± 6.0% of saline control at 1T and 3/2T, respectively) as S2 DRG stimulation (increases BC to 58.3 ± 3.7 and 65.6 ± 3.7% of control).
Conclusion
This study showed the effective inhibition on bladder activity under both non-nociceptive and nociceptive conditions, suggesting the possibility of sacral DRG stimulation to treat bladder overactivity.
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Acknowledgements
This study were funded by the National Natural Science Foundation of China (No. 81570688) and Research Projects of China Rehabilitation Research Centre (2017ZX-31).
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Protocol/project development: LL and ZW; data collection or management: ZW, XL, GC, and HD; data analysis: ZW; and manuscript writing/editing: ZW.
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The authors declare that they have no conflict of interest.
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Human subjects were not used in this study. All animal experiments were performed ethically in accordance with Capital Medical University guidelines for animal care and use.
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Wang, Z., Liao, L., Deng, H. et al. The inhibitory effect of sacral dorsal root ganglion stimulation on nociceptive and nonnociceptive bladder reflexes in cats. World J Urol 36, 829–836 (2018). https://doi.org/10.1007/s00345-018-2198-6
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DOI: https://doi.org/10.1007/s00345-018-2198-6