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Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent

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Abstract

Background

Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.

Methods

Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.

Results

ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).

Conclusions

ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.

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Funding

A. Mbeutcha received a Grant from Association des Amis de la Faculté de médecine de Nice.

Authors’ contribution

Aurélie Mbeutcha and Ilaria Lucca managed and analyzed the data, and wrote and edited the manuscript; Vitaly Margulis developed the protocol, collected and managed the data, and edited the manuscript; Jose A. Karam and Christopher G. Wood collected the data and edited the manuscript; Michela de Martino and Romain Mathieu edited the manuscript; Andrea Haitel collected the data; Evanguelos Xylinas, Luis Kluth, Morgan Rouprêt, Pierre I. Karakiewicz, Alberto Briganti, Michael Rink, Malte Rieken, Alon Z. Weizer, Jay D. Raman, Christian Bolenz, and Karim Bensalah collected the data and edited the manuscript; Nathalie Rioux-Leclecq collected the data; Yair Lotan developed the protocol, collected and managed the data, and edited the manuscript; Christian Seitz and Mesut Remzi collected the data; Shahrokh F. Shariat and Tobias Klatte developed the project, collected, managed, and analyzed the data, and wrote and edited the manuscript.

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Author notes

    Authors and Affiliations

    1. Department of Urology, Vienna General Hospital, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

      Aurélie Mbeutcha, Ilaria Lucca, Michela de Martino, Romain Mathieu, Malte Rieken, Christian Seitz, Shahrokh F. Shariat & Tobias Klatte

    2. Department of Urology, Hôpital Archet 2, Centre Hospitalier Universitaire de Nice, University of Nice Sophia-Antipolis, Nice, France

      Aurélie Mbeutcha

    3. Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

      Ilaria Lucca

    4. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA

      Vitaly Margulis, Yair Lotan & Shahrokh F. Shariat

    5. Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

      Jose A. Karam & Christopher G. Wood

    6. Department of Urology, Rennes University Hospital, Rennes, France

      Romain Mathieu & Karim Bensalah

    7. Department of Pathology, Medical University of Vienna, Vienna, Austria

      Andrea Haitel

    8. Department of Urology Cochin Hospital, APHP, Paris Descartes University, Paris, France

      Evanguelos Xylinas

    9. Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

      Luis Kluth & Michael Rink

    10. Department of Urology, Pitié-Salpétrière, Assistance-Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France

      Morgan Rouprêt

    11. Department of Urology, University of Montreal, Montreal, QC, Canada

      Pierre I. Karakiewicz

    12. Dipartimento di Urologia, Ospedale S. Raffaele, Università Vita-Salute, Milan, Italy

      Alberto Briganti

    13. Department of Urology, University Hospital Basel, Basel, Switzerland

      Malte Rieken

    14. Department of Urology, University of Michigan, Ann Arbor, MI, USA

      Alon Z. Weizer

    15. Division of Urology, Penn State Milton S.Hershey Medical Center, Hershey, PA, USA

      Jay D. Raman

    16. Department of Pathology, University of Rennes, Rennes, France

      Nathalie Rioux-Leclecq

    17. Department of Urology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany

      Christian Bolenz

    18. Department of Urology, Landeskrankenhaus Weinviertel-Korneuburg, Korneuburg, Austria

      Mesut Remzi

    19. Department of Urology, Weill Cornell Medical College, New York, NY, USA

      Shahrokh F. Shariat

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    1. Aurélie Mbeutcha
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    2. Ilaria Lucca
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    Corresponding author

    Correspondence to Shahrokh F. Shariat.

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    The authors declare that they have no conflict of interest.

    Additional information

    Aurélie Mbeutcha and Ilaria Lucca have contributed equally as co-first authors.

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    Cite this article

    Mbeutcha, A., Lucca, I., Margulis, V. et al. Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent. World J Urol 34, 1155–1161 (2016). https://doi.org/10.1007/s00345-015-1737-7

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    • DOI: https://doi.org/10.1007/s00345-015-1737-7

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