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A compact laser-based spectrometer for detection of C2H2 in exhaled breath and HCN in vitro

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Abstract

We report on the development of a compact prototype near-infrared DBR laser-based spectrometer employing off-axis integrated cavity output spectroscopy. The spectrometer is capable of simultaneous detection of acetylene (C2H2) and CO2 at 1,529.2 nm as well as hydrogen cyanide (HCN) at 1,533.5 nm. The detection limits of 8 ppbv for C2H2 and 80 ppbv for HCN are achieved for the acquisition time of 1 s. The setup has been tested for online measurements of C2H2 in exhaled breath of a smoking subject and HCN resulting from the metabolism of Pseudomonas aeruginosa bacteria in vitro. Further improvements of the performance of the spectrometer are discussed.

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Acknowledgments

This work was supported by the GO-EFRO Ultragas, Project No. 2009-010034 of province of Gelderland (The Netherlands) and EU, EU-Marie Curie fellowships EU-people-2010-IEF, Project No. 275584, and IOP-Photonics, Project No. IPD100025. Authors would like to thank Microbiology Department at Radboud University Medical Center (Nijmegen, the Netherlands) for providing PsA strains.

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Authors and Affiliations

  1. Life Science Trace Gas Facility, Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, P.O. Box 9010, 6500 GL, Nijmegen, The Netherlands

    D. Marchenko, A. H. Neerincx, J. Mandon, S. M. Cristescu & F. J. M. Harren

  2. VTEC Lasers and Sensors Limited, Torenallee 20, 5617 BC, Eindhoven, The Netherlands

    J. Zhang, M. Boerkamp & J. Mink

  3. Sensor Sense BV, St. Agnetenweg 103, 6545 AV, Nijmegen, The Netherlands

    S. te Lintel Hekkert

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  1. D. Marchenko
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  2. A. H. Neerincx
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Correspondence to D. Marchenko.

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Marchenko, D., Neerincx, A.H., Mandon, J. et al. A compact laser-based spectrometer for detection of C2H2 in exhaled breath and HCN in vitro. Appl. Phys. B 118, 275–280 (2015). https://doi.org/10.1007/s00340-014-5983-y

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  • DOI: https://doi.org/10.1007/s00340-014-5983-y

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