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Visualization of lenticulostriate artery by intracranial dark-blood vessel wall imaging and its relationships with lacunar infarction in basal ganglia: a retrospective study

  • Magnetic Resonance
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Abstract

Objectives

There is close relationship between lenticulostriate arteries (LSAs) and lacunar infarctions (LIs) of the basal ganglia. The study aims to visualize the LSAs using high-resolution vessel wall imaging (VWI) on 3T system and explore the correlation between LSAs and LIs.

Methods

Fifty-six patients with LIs in basal ganglia, and 44 age-matched control patients were enrolled and analyzed retrospectively. The raw VWI images were reformatted into coronal slices in minimum intensity projection for further observation of LSAs. The risk factors of LIs in basal ganglia were analyzed by univariate and multivariate logistic regression. The correlation and linear regression analysis between the LSAs and LIs, ipsilateral MCA-M1 plaques were investigated.

Results

The total number (p < 0.01) and length (p < 0.01) of LSAs were statistically different between basal ganglias with and without LIs. The total number of LSAs and ipsilateral MCA-M1 plaques were independently related to LIs in basal ganglias. The mean length of LSAs were negatively correlated with number (r = − 0.33, p = 0.002) and volume (r = − 0.37, p = 0.001) of LIs. Age, drinking history, and mean length of LSAs were associated with LI occurrence in basal ganglia, and mean length of LSAs was correlated with larger volume of LIs.

Conclusions

Number of LSA reduction and ipsilateral MCA-M1 plaques were associated with the presence of LIs in basal ganglias. Age increasing, drinking history, and shorter LSAs were correlated with the increasing of LIs.

Key Points

• Patients with LIs tend to have shorter LSAs.

• The characteristics of LSAs and ipsilateral MCA-M1 plaques are associated with LIs in basal ganglias.

• Age, drinking history, and mean length of LSAs are correlated with LI features in basal ganglias.

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Abbreviations

CI:

Confidence interval

DWI:

Diffusion-weighted imaging

FLAIR:

Fluid-attenuated inversion recovery

ICA:

Internal carotid artery

ICA:

Internal carotid artery

ICC:

Interclass correlation coefficient

LIs:

Lacunar infarctions

LSAs:

Lenticulostriate arteries

MCA:

Middle cerebral artery

MinIP:

Minimum intensity projection

MRA:

Magnetic resonance angiography

MRI:

Magnetic resonance imaging

SPACE:

Sampling perfection with application-optimized contrast using different flip angle evolutions

T1WI:

T1-weighted imaging

T2WI:

T2-weighted imaging

VWI:

Vessel wall imaging

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Acknowledgments

The authors thank Chao Chai for statistical consultation and Jinxia Zhu for amending the abstract, and thank Tianjin First Central Hospital for providing convenience of finishing this research paper.

Funding

This work was supported in part by the Natural Scientific Foundation of China (grant number 81871342 to Shuang Xia), the National Institutes of Health (NIH/NHLBI 1 R01 HL147355), and the Tianjin First Central Hospital Fund (grant number 2019CM05 to Yu Guo).

Author information

Author notes

  1. Weiwei Xie and Chen Wang contributed equally to the manuscript as first author

Authors and Affiliations

  1. Department of Radiology, Tianjin First Central Clinical College, Medical University of Tianjin, Tianjin, China

    Weiwei Xie, Song Liu, Ruowei Tang, Shengting Chai & Shuang Xia

  2. Department of Radiology, Fifth Affiliated Hospital of Sun Yat sen University, Zhuhai, Guangdong, China

    Weiwei Xie

  3. Department of Neurosurgery, Tianjin First Central Hospital, Tianjin, China

    Chen Wang & Binge Chang

  4. Department of Radiology, Tianjin First Central Hospital, Tianjin, China

    Yu Guo

  5. Siemens Healthcare, MR Collaborations NE Asia, Beijing, China

    Tianyi Qian

  6. Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China

    Qi Yang

  7. Cedars-Sinai Medical Center, 8700 Beverly Blvd, Pacific Theatres, Suite 400, Los Angeles, CA, 90048, USA

    Zhaoyang Fan

  8. Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Number 24 of Fukang Road, Nankai District, Tianjin, 300192, China

    Shuang Xia

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Correspondence to Shuang Xia.

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The scientific guarantor of this publication is Shuang Xia.

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One of the authors of this manuscript (Tianyi Qian) is an employee of Siemens Healthcare. The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article.

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Chao Chai kindly provided statistical advice for this manuscript.

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• case-control study

• performed at one institution

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Xie, W., Wang, C., Liu, S. et al. Visualization of lenticulostriate artery by intracranial dark-blood vessel wall imaging and its relationships with lacunar infarction in basal ganglia: a retrospective study. Eur Radiol 31, 5629–5639 (2021). https://doi.org/10.1007/s00330-020-07642-7

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