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Diagnostic value of the acute angle between the prestenotic and poststenotic duodenum in neonatal annular pancreas

  • Ultrasound
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To analyze the ability of upper gastrointestinal (GI) saline-contrast ultrasound (US) to detect neonatal annular pancreas.

Methods

Sixty-two neonates, who presented duodenal obstruction and were examined by upper GI saline-contrast US before treatment, were retrospectively analyzed and categorized into four groups according to their final diagnosis: group A, annular pancreas (n = 28); group B, duodenal atresia (n = 2); group C, descending duodenal septum (n = 25); and group D, normal (n = 7). The ultrasonic characteristics were analyzed that especially focused on whether the angle between the prestenotic and poststenotic descending duodenum (at or below a derived cutoff) could identify neonatal annular pancreas.

Results

To detect annular pancreas using the concave contour of the distal prestenotic duodenum, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined at 71.4%, 100%, 100%, and 80.9%, respectively. When using the hyperechogenic band around the constricted duodenum, the sensitivity, specificity, PPV, and NPV were determined at 82.1%, 94.1%, 92%, and 86.5%, respectively. For using the 40.7° acute angle cutoff between prestenotic and poststenotic descending duodenum, the values of sensitivity, specificity, PPV, and NPV were determined at 100%, 97.1%, 96.6%, and 100%, respectively, of which the area under the receiver operating characteristic curve was 0.979.

Conclusions

Upper GI saline-contrast US has a lower possibility for misdiagnosis of neonatal annular pancreas when considering the acute angle between the prestenotic and poststenotic descending duodenum.

Key Points

• This study includes the largest series of neonates with annular pancreas of which the characteristics were analyzed using the upper GI saline-contrast US.

• Neonatal annular pancreas may be diagnosed by the characteristics—concave contour of the distal prestenotic duodenum; acute angle cutoff of 40.7° between the prestenotic and poststenotic duodenum; the “S” shape formed by the pylorus, the duodenal bulb, and the prestenotic and poststenotic descending duodenum.

• The acute angle with the highest diagnostic value can be used to quantitatively diagnose neonatal annular pancreas and avoid potential misdiagnosis caused by sonographers’ subjectivity.

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Abbreviations

AUC:

Area under the ROC curve

GI:

Gastrointestinal

NPV:

Negative predictive value

PPV:

Positive predictive value

ROC:

Receiver operating characteristic

US:

Ultrasound

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Acknowledgements

The authors express heartfelt gratitude to Bin Yan and Ruen Zhao who helped with collecting the data.

Funding

This study has received funding from the Guangzhou Institute of Pediatrics/Guangzhou Women and Children’s Medical Center (no. IP-2018-015).

Author information

Authors and Affiliations

  1. Department of Medical Ultrasonics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, No. 9 Jin Sui Road, Guangzhou, 510623, China

    Boyang Yang, Qian Fang & Hongying Wang

  2. Department of Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

    Fan He

  3. Department of Neonatal Surgery and Neonatal Surgical Intensive Care Unit, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

    Qiuming He, Zhe Wang & Wei Zhong

Authors
  1. Boyang Yang
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  2. Fan He
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  3. Qiuming He
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  4. Zhe Wang
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  5. Qian Fang
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  6. Wei Zhong
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  7. Hongying Wang
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Corresponding authors

Correspondence to Wei Zhong or Hongying Wang.

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Guarantor

The scientific guarantor of this publication is Dr. Hongying Wang.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• retrospective

• diagnostic or prognostic study

• performed at one institution

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Yang, B., He, F., He, Q. et al. Diagnostic value of the acute angle between the prestenotic and poststenotic duodenum in neonatal annular pancreas. Eur Radiol 29, 2902–2909 (2019). https://doi.org/10.1007/s00330-018-5922-0

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  • DOI: https://doi.org/10.1007/s00330-018-5922-0

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