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Volume doubling time of lung cancer detected in idiopathic interstitial pneumonia: comparison with that in chronic obstructive pulmonary disease

  • Chest
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Abstract

Objectives

To assess the volume doubling time (VDT) of lung cancers in IIP compared with COPD.

Methods

A total of 61 patients (32 with IIP and 29 with COPD) were identified. A radiologist performed three-dimensional manual segmentation for lung cancers. VDTs were calculated and compared between two groups. Logistic regression was performed to identify factors associated with rapid tumour growth (VDT < 90 days).

Results

The median VDT of lung cancers in IIP (78.2 days) was significantly shorter than that in COPD (126.1 days; p=0.004). Squamous cell carcinoma (SqCC) was the most frequent subtype, followed by small cell lung cancer (SCLC) in IIP. In COPD, SqCC was the most frequent subtype, followed by adenocarcinoma. Rapid tumour growth was observed in 20 cancers from IIP, and in nine cancers from COPD (p=0.021). SCLC was significantly correlated with rapid tumour growth (p=0.038). Multivariate analysis revealed that the presence of IIP was the single independent predictor of rapid tumour growth (p = 0.016; odds ratio, 3.7).

Conclusions

Lung cancers in IIP showed more rapid growth, with median VDT < 90 days. Therefore, a shorter follow-up interval (<90 days) may be necessary when CT surveillance is considered in IIP patients with suspected lung cancer.

Key Points

• The median VDTs of lung cancers in IIP was 78.2 days.

• Rapid tumour growth occurred more frequently in IIP than in COPD.

• IIP was the single independent predictor of rapid tumour growth.

• Shorter CT follow-up interval may be necessary in IIP with suspicious nodules.

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Abbreviations

COPD:

Chronic obstructive pulmonary disease;

CT:

Computed tomography;

FEV1:

Forced expiratory volume in 1 s;

FVC:

Forced volume vital capacity;

IIP:

Idiopathic interstitial pneumonia;

SCLC:

Small cell lung cancer;

SqCC:

Squamous cell carcinoma;

VDT:

Volume doubling time

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Funding

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant number: NRF-2016R1A2B1016355).

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Authors and Affiliations

  1. Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Centre, 88 Olympic-ro 43 gil, Songpa-Gu, Seoul, 05505, Korea

    Cherry Kim, Sang Min Lee, Jooae Choe, Eun Jin Chae, Kyung-Hyun Do & Joon Beom Seo

  2. Department of Radiology, Ansan Hospital, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, 15355, Gyeonggi, Korea

    Cherry Kim

Authors
  1. Cherry Kim
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Corresponding author

Correspondence to Sang Min Lee.

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Guarantor

The scientific guarantor of this publication is Sang Min Lee.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Study subjects or cohorts overlap

Of 32 patients with IIP, five were identical to the study population in the previous report (Oh et al. [reference 11]). Oh et al.’s study dealt with CT features of lung cancers detected during follow up of idiopathic interstitial pneumonia, whereas this work addressed VDTs of lung cancer in IIP and compared with VDTs of lung cancer in COPD patients. Thus, this work is substantially different from previous reports.

Methodology

• retrospective

• case-control study

• performed at one institution

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Kim, C., Lee, S.M., Choe, J. et al. Volume doubling time of lung cancer detected in idiopathic interstitial pneumonia: comparison with that in chronic obstructive pulmonary disease. Eur Radiol 28, 1402–1409 (2018). https://doi.org/10.1007/s00330-017-5091-6

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  • DOI: https://doi.org/10.1007/s00330-017-5091-6

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