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Left ventricular regional myocardial motion and twist function in repaired tetralogy of Fallot evaluated by magnetic resonance tissue phase mapping

  • Magnetic Resonance
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Abstract

Objectives

We aimed to characterise regional myocardial motion and twist function in the left ventricles (LV) in patients with repaired tetralogy of Fallot (rTOF) and preserved LV global function.

Methods

We recruited 47 rTOF patients and 38 age-matched normal volunteers. Tissue phase mapping (TPM) was performed for evaluating the LV myocardial velocity in longitudinal, radial, and circumferential (Vz, Vr, and VØ) directions in basal, middle, and apical slices. The VØ peak-to-peak (PTP) during systolic phases, the rotation angle of each slice, and VØ inconsistency were computed for evaluating LV twist function and VØ dyssynchrony.

Results

As compared to the controls, the rTOF patients presented decreased RV ejection fraction (RVEF) (p = 0.002) and preserved global LV ejection fraction (LVEF). They also demonstrated decreased systolic and diastolic Vz in several LV segments and higher diastolic Vr in the septum (all p < 0.05). A lower VØ PTP, higher VØ inconsistency, and reduced peak net rotation angle (all p < 0.05) were observed. The aforementioned indices demonstrated an altered LV twist function in rTOF patients in an early disease stage.

Conclusions

MR TPM could provide information about early abnormalities of LV regional motion and twist function in rTOF patients with preserved LV global function.

Key points

• Patients with rTOF presented significantly reduced systolic and diastolic Vz in the LV.

• rTOF patients demonstrated significantly increased diastolic Vr in the septum.

• Abnormal characteristics of the segmental dynamic velocity evolution were shown in rTOF.

• rTOF patients presented altered circumferential rotation and velocity inconsistency in early stage.

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Abbreviations

EF:

ejection fraction

LV:

left ventricle

PR:

pulmonary regurgitation

PTP:

peak to peak

rTOF:

repaired tetralogy of Fallot

RV:

right ventricle

TPM:

tissue phase mapping

TTP:

time-to-peak

Vr:

radial velocity

VØ:

circumferential velocity

Vz:

longitudinal velocity

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Acknowledgements

Parts of the work have been presented in the 23rd Annual Meeting of International Society of Magnetic Resonance in Medicine, Toronto, Canada.

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Authors and Affiliations

  1. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No.101, Sec. 2, Kuang-Fu Rd., BMES Building, R415, Hsinchu, 300, Taiwan

    Meng-Chu Chang & Hsu-Hsia Peng

  2. Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

    Ming-Ting Wu & Hung-Chieh Huang

  3. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

    Ming-Ting Wu & Ken-Pen Weng

  4. Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

    Ken-Pen Weng

  5. Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan

    Ken-Pen Weng

  6. Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

    Mao-Yuan Su

  7. Department of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Marius Menza

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  1. Meng-Chu Chang
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  2. Ming-Ting Wu
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  4. Mao-Yuan Su
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  6. Hung-Chieh Huang
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Corresponding author

Correspondence to Hsu-Hsia Peng.

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Guarantor

The scientific guarantor of this publication is Dr. Hsu-Hsia Peng.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Funding

This study has received funding by the Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1, VGHUST103-G3-1-2, VGHUST104-G7-7-1, VGHUST104-G7-7-2, and VGHUST104-G7-7-3). This study was also supported in part by Ministry of Science and Technology in Taiwan (NSC 102-2320-B-007-003-MY3).

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• cross sectional study

• performed at one institution

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Chang, MC., Wu, MT., Weng, KP. et al. Left ventricular regional myocardial motion and twist function in repaired tetralogy of Fallot evaluated by magnetic resonance tissue phase mapping. Eur Radiol 28, 104–114 (2018). https://doi.org/10.1007/s00330-017-4908-7

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  • DOI: https://doi.org/10.1007/s00330-017-4908-7

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