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Percutaneous transluminal forceps biopsy in patients suspected of having malignant biliary obstruction: factors influencing the outcomes of 271 patients

  • Interventional
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To evaluate predictive factors for false-negative diagnosis of percutaneous forceps biopsies in patients suspected of having a malignant biliary obstruction

Methods

Two hundred seventy one consecutive patients with obstructive jaundice underwent percutaneous forceps biopsy. In each patient, three to five specimens (mean, 3.5 specimens) were collected from the lesion. The final diagnosis for each patient was confirmed with pathologic findings at surgery, additional histocytologic data, or clinical and radiologic follow-up. Univariate and multivariate logistic regression analysis was used to identify risk factors associated with false-negative diagnosis.

Results

One hundred ninety four of 271 biopsies resulted in correct diagnoses of malignancy, while 20 biopsy diagnoses were proved to be true-negative. There were 57 false-negative diagnoses and no false-positive diagnoses. The diagnostic performance of transluminal forceps biopsy in malignant biliary obstructions was as follows: sensitivity, 77.2%; specificity, 100%; and accuracy, 78.9%; positive predictive value, 100%, negative predictive value; 25.9%. Periampullary segment of common bile duct, intrahepatic bile duct and metastatic disease were the significant risk factors of false-negative diagnosis.

Conclusions

Percutaneous forceps biopsy provides relatively high accuracy in the diagnosis of malignant biliary obstructions. The predictive factors of false-negative biopsy were determined to be biopsy site and origin of primary tumour.

Key Points

• Percutaneous forceps biopsy provides relatively high accuracy in diagnosis of malignant biliary obstructions.

• The predictive factors of false-negative biopsy were biopsy site and origin of primary tumour.

• The procedure-related complications were low.

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Abbreviations

CI:

Confidence interval

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Author information

Authors and Affiliations

  1. Department of Radiology, Kosin University College of Medicine, 262, Gamcheon-ro, Seo-gu, Busan, Korea

    Jung Gu Park, Gyoo-Sik Jung & Jong Hyouk Yun

  2. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea

    Byung Chul Yun, Sang Uk Lee & Byung Hoon Han

  3. Department of Radiology, Busan Medical Center, Busan, Korea

    Ji Ho Ko

Authors
  1. Jung Gu Park
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  2. Gyoo-Sik Jung
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  4. Byung Chul Yun
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  5. Sang Uk Lee
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Corresponding author

Correspondence to Gyoo-Sik Jung.

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Guarantor

The scientific guarantor of this publication is Gyoo-Sik Jung, MD.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Funding

The authors state that this work has not received any funding.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consents were obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Study subjects or cohorts overlap

Some study subjects or cohorts have been previously reported in Radiology. Jung G, Huh J, Lee SU, Han BH, Chang H, Cho YD (2002) Bile duct: analysis of percutaneous transluminal forceps biopsy in 130 patients suspected of having malignant biliary obstruction. Radiology 224:725-730.

Methodology

• Retrospective

• Diagnostic study

• Performed at one institution

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Cite this article

Park, J.G., Jung, GS., Yun, J.H. et al. Percutaneous transluminal forceps biopsy in patients suspected of having malignant biliary obstruction: factors influencing the outcomes of 271 patients. Eur Radiol 27, 4291–4297 (2017). https://doi.org/10.1007/s00330-017-4796-x

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  • DOI: https://doi.org/10.1007/s00330-017-4796-x

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