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Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators

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Abstract

Objectives

To retrospectively review the clinical, radiological and pathological data in patients who underwent surgical resection for pulmonary pleomorphic carcinoma (PC), and to analyse the prognostic predictors of survival.

Methods

The data were retrospectively examined for 33 consecutive patients (28 males and five females) who had undergone surgical resection for pulmonary PC. Cox’s proportional-hazards model was used to analyse the prognostic predictors of survival.

Results

The size of the tumours ranged from 1.1 to 12.0 cm (mean 5.4 cm). The majority (26) of the tumours were located at the lung periphery, five tumours had cavitation, two had calcification and 14 had peritumoral ground-glass opacity. Most of the tumours showed heterogeneous enhancement and contained a low-density area (LDA) within the tumour. The 5-year overall survival of surgically resected PC was 36 % (standard error = 0.093). A multivariate analysis revealed the LDA grade [hazard ratio (HR), 2.019], pathological stage (HR, 7.552) and pathological N factor (HR, 0.370) to be significant predictors of a poorer prognosis.

Conclusions

A greater component of LDA within the tumour on contrast-enhanced CT is associated with a poorer prognosis in patients with PC.

Key Points

• PC has a poorer prognosis than other conventional NSCLC.

• The five-year OS of surgically resected PC was 36 %.

• A greater component of LDA on contrast-enhanced CT suggests a poorer prognosis.

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Abbreviations

PC:

Pleomorphic carcinoma

NSCLC:

Non-small-cell lung carcinoma

GGO:

Ground-glass opacity

LDA:

Low-density area

OS:

Overall survival

HR:

Hazard ratio

References

  1. Pelosi G, Sonzogni A, De Pas T, Galetta D, Veronesi G, Spaggiari L et al (2010) Pulmonary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol 18:103–120

    Article  PubMed  Google Scholar 

  2. Travis WD (2010) Sarcomatoid neoplasms of the lung and pleura. Arch Pathol Lab Med 134:1645–1658

    PubMed  Google Scholar 

  3. Mochizuki T, Ishii G, Nagai K, Yoshida J, Nishimura M, Mizuno T et al (2008) Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. Am J Surg Pathol 32:1727–1735

    Article  PubMed  Google Scholar 

  4. Yuki T, Sakuma T, Ohbayashi C, Yoshimura M, Tsubota N, Okita Y et al (2007) Pleomorphic carcinoma of the lung: a surgical outcome. J Thorac Cardiovasc Surg 134:399–404

    Article  PubMed  Google Scholar 

  5. Chen F, Sonobe M, Sato T, Sakai H, Huang CL, Bando T et al (2012) Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma. Eur J Cardiothorac Surg 41:1037–1042

    Article  PubMed  Google Scholar 

  6. Ito K, Oizumi S, Fukumoto S, Harada M, Ishida T, Fujita Y et al (2010) Clinical characteristics of pleomorphic carcinoma of the lung. Lung Cancer 68:204–210

    Article  PubMed  Google Scholar 

  7. Kim TH, Kim SJ, Ryu YH, Lee HJ, Goo JM, Im JG et al (2004) Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. Radiology 232:554–559

    Article  PubMed  Google Scholar 

  8. Kim TS, Han J, Lee KS, Jeong YJ, Kwak SH, Byun HS et al (2005) CT findings of surgically resected pleomorphic carcinoma of the lung in 30 patients. AJR Am J Roentgenol 185:120–125

    Article  PubMed  Google Scholar 

  9. Martin LW, Correa AM, Ordonez NG, Roth JA, Swisher SG, Vaporciyan AA et al (2007) Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg 84:973–980

    Article  PubMed  Google Scholar 

  10. Yendamuri S, Caty L, Pine M, Adem S, Bogner P, Miller A et al (2012) Outcomes of sarcomatoid carcinoma of the lung: a Surveillance, Epidemiology, and End Results Database analysis. Surgery 152:397–402

    Article  PubMed  Google Scholar 

  11. Sonomura T, Noda Y, Sato M, Sanda H, Ishii S, Kawai N et al (2010) Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. Clin Nucl Med 35:717–719

    Article  PubMed  Google Scholar 

  12. Vieira T, Girard N, Ung M, Monnet I, Cazes A, Bonnette P et al (2013) Efficacy of first-line chemotherapy in patients with advanced lung sarcomatoid carcinoma. J Thorac Oncol 8:1574–1577

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The scientific guarantor of this publication is Prof. Dr. Kazuto Ashizawa. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational, performed at one institution.

The collection of the cancer data used in this study was supported in part by the cancer registry of Nagasaki prefecture.

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Authors and Affiliations

  1. Department of Clinical Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Akifumi Nishida & Kazuto Ashizawa

  2. Department of Radiological Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Hideyuki Hayashi & Masataka Uetani

  3. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Keitaro Matsumoto, Tomoshi Tsuchiya, Naoya Yamasaki & Takeshi Nagayasu

  4. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Naoe Kinoshita

  5. Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Sumihisa Honda

  6. Department of Pathology, Nagasaki Prefectural Shimabara Hospital, 7895 Shimokawashiri, Shimabara, 855-0861, Japan

    Tomayoshi Hayashi

  7. Department of Radiology, Saga National Hospital, 1-20-1 Hinode, Saga, 849-8577, Japan

    Hajime Abiru

Authors
  1. Akifumi Nishida
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  2. Hajime Abiru
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  3. Hideyuki Hayashi
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  4. Masataka Uetani
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  5. Keitaro Matsumoto
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  6. Tomoshi Tsuchiya
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  7. Naoya Yamasaki
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  8. Takeshi Nagayasu
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  9. Tomayoshi Hayashi
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  10. Naoe Kinoshita
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  11. Sumihisa Honda
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  12. Kazuto Ashizawa
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Corresponding author

Correspondence to Kazuto Ashizawa.

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Nishida, A., Abiru, H., Hayashi, H. et al. Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. Eur Radiol 26, 25–31 (2016). https://doi.org/10.1007/s00330-015-3811-3

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  • DOI: https://doi.org/10.1007/s00330-015-3811-3

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