Abstract
Objectives
To compare CT lung volumetry (CTLV) measurements provided by different software packages, and to provide normative data for lung densitometric measurements in healthy individuals.
Methods
This retrospective study included 51 chest CTs of 17 volunteers (eight men and nine women; mean age, 30 ± 6 years), who underwent spirometrically monitored CT at total lung capacity (TLC), functional residual capacity (FRC), and mean inspiratory capacity (MIC). Volumetric differences assessed by four commercial software packages were compared with analysis of variance (ANOVA) for repeated measurements and benchmarked against the threshold for acceptable variability between spirometric measurements. Mean lung density (MLD) and parenchymal heterogeneity (MLD-SD) were also compared with ANOVA.
Results
Volumetric differences ranged from 12 to 213 ml (0.20 % to 6.45 %). Although 16/18 comparisons (among four software packages at TLC, MIC, and FRC) were statistically significant (P < 0.001 to P = 0.004), only 3/18 comparisons, one at MIC and two at FRC, exceeded the spirometry variability threshold. MLD and MLD-SD significantly increased with decreasing volumes, and were significantly larger in lower compared to upper lobes (P < 0.001).
Conclusions
Lung volumetric differences provided by different software packages are small. These differences should not be interpreted based on statistical significance alone, but together with absolute volumetric differences.
Key Points
• Volumetric differences, assessed by different CTLV software, are small but statistically significant.
• Volumetric differences are smaller at TLC than at MIC and FRC.
• Volumetric differences rarely exceed spirometric repeatability thresholds at MIC and FRC.
• Differences between CTLV measurements should be interpreted based on comparison of absolute differences.
• MLD increases with decreasing volumes, and is larger in lower compared to upper lobes.
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Acknowledgments
The scientific guarantor of this publication is Professor Dr. Alexander A. Bankier. A. A. Bankier is a consultant for Spiration (Olympus Medical Systems) and has received authorship honoraria from Elsevier. No conflict of interest is known from the other co-authors. The authors state that this work has not received any funding. Professor Dr. Alexander A. Bankier (senior author) has significant statistical expertise and provided statistical advice for this manuscript. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Our study population was a group of healthy volunteers that had served as control subjects in a previous clinical study (Dufresne V. et al. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis. Am J Respir Crit Care Med 2009). Institutional Review Board approval was obtained for both the initial CT data acquisitions on which this study was based, and for the analysis of the CT data for the current retrospective study. Methodology: retrospective, performed at one institution.
Conflict of interest
A. A. Bankier is a consultant for Spiration (Olympus Medical Systems) and has received authorship honoraria from Elsevier. No conflict of interest is known from the other co-authors. The authors state that this work has not received any funding.
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Nemec, S.F., Molinari, F., Dufresne, V. et al. Comparison of four software packages for CT lung volumetry in healthy individuals. Eur Radiol 25, 1588–1597 (2015). https://doi.org/10.1007/s00330-014-3557-3
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DOI: https://doi.org/10.1007/s00330-014-3557-3