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The relationship between vitamin D receptor gene polymorphisms and ankylosing spondylitis: a systematic review, meta-analysis and trial sequential analysis

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Abstract

The relation between vitamin D receptor (VDR) gene polymorphisms and ankylosing spondylitis (AS) remains unclear. A systematic review and meta-analysis were conducted using six databases, including PubMed, Web of Science, EMBASE, CNKI, Wanfang and Cochrane Library. The selection of each study was based on inclusion and exclusion criteria. The Newcastle–Ottawa Scale was applied to assess the quality of the included studies, while the strength was evaluated by odds ratios and 95% confidence intervals. The following contrasts were used: allele contrast (H vs h), homozygous contrast (HH vs hh), heterozygous contrast (Hh vs hh), dominant contrast (HH + Hh vs hh) and recessive contrast (HH vs Hh + hh). For the BsmI-rs1544410 polymorphism, three studies were included of 782 cases and 863 controls. The data showed a significant relationship under allele contrast H vs h (OR = 1.66, 95% CI 1.20–2.30 (P = 0.002)). For the TaqI-rs731236 polymorphism, 675 cases and 697 controls were included in two studies. The data showed a significant relationship under allele contrast H vs h (OR = 1.57, 95% CI 1.11–2.21 (P < 0.05)), homozygous contrast Hh vs hh (OR = 1.65, 95% CI 1.12–2.43 (P < 0.05)), and recessive contrast HH + Hh vs hh (OR = 1.66, 95% CI 1.13–2.43 (P < 0.05)). There were significant relationships between VDR gene BsmI-rs1544410 and TaqI-rs731236 polymorphisms and AS, while no associations were found between FokI-rs2228570 and ApaI-rs7975232 polymorphisms and AS. In the future, additional studies with larger case numbers are need.

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Data availability

The data are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Rheumatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Hang Zhou

  2. Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Bo-Yang Zhou, Su-Rong Liang & Jian Zhao

  3. Clinical Epidemiology and Evidence-Based Medicine Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Min Li

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HZ and JZ have made substantial contributions to conception and design of the study, written the manuscript. BZ, ML and SL searched literature, extracted data from the collected literature and analyzed the data; HZ revised the manuscript; all authors approved the final version of the manuscript.

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Correspondence to Jian Zhao.

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Zhou, H., Zhou, BY., Liang, SR. et al. The relationship between vitamin D receptor gene polymorphisms and ankylosing spondylitis: a systematic review, meta-analysis and trial sequential analysis. Rheumatol Int 43, 21–32 (2023). https://doi.org/10.1007/s00296-022-05189-y

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