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Sacroiliac joint in sarcoidosis on computed tomography: a monocentric retrospective study (SISTER)

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Abstract

Sacroiliitis and spondyloarthritis (SpA) have been associated to sarcoidosis. Sarcoidosis bone involvement of the sacral or iliac bones has been reported to mimic SpA. We aimed to evaluate the prevalence of structural sacroiliitis and structural changes of the sacroiliac joints (SIJ) in patients with sarcoidosis by abdominal–pelvic computed tomography (AP-CT). In this monocentric retrospective study, three blinded readers evaluated AP-CT that had already been performed on patients with sarcoidosis and classified them as normal, degenerative, or inflammatory. A consensus was reached for the divergent cases. Erosion, ankylosis, and sclerosis, classically associated with sacroiliitis, were noted. SpA was defined according to the ASAS 2009 classification criteria. We identified 217 patients with proven sarcoidosis who underwent AP-CT. Only three patients had sacroiliitis by CT and four had SpA, representing 1.38% and 1.85% of the patients, respectively. Degenerative SIJs represented 28.1% of patients and were significantly associated with age, at least one pregnancy, rural lifestyle, ankylosis, diffuse idiopathic skeletal hyperostosis, sclerosis, and the presence of osteophytes. Four patients had axial bone sarcoidosis. Sacroiliitis, SpA, and degenerative changes of the SIJ have been highlighted by AP-CT in patients with sarcoidosis. Osteoarthritis of the SIJ in sarcoidosis was associated with age, pregnancy, and rural lifestyle. Further studies are needed to assess the link between SpA and sarcoidosis.

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Authors and Affiliations

  1. Department of Rheumatology, Rennes University Hospital, Hôpital Sud, University of Rennes 1, 16 Boulevard de Bulgarie, 35000, Rennes, France

    Simon Cadiou, Aleth Perdriger & Pascal Guggenbuhl

  2. Department of Rheumatology, Dinan Hospital, 22000, Dinan, France

    Guillaume Coiffier

  3. Department of Respiratory Medicine, Rennes University Hospital, Rennes, France

    Stéphane Jouneau

  4. University of Rennes 1, Rennes, France

    Stéphane Jouneau

  5. INSERM-IRSET UMR1085, Rennes, France

    Stéphane Jouneau

  6. Internal Medicine Department, Rennes University Hospital, University of Rennes 1, 35000, Rennes, France

    Patrick Jego

  7. Internal Medicine Department, Rennes University Hospital, 35000, Rennes, France

    Nicolas Belhomme

  8. Department of Medical Imaging, Rennes University Hospital, 35000, Rennes, France

    Raphaël Guillin

  9. INSERM, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), UMR 1241, Univ Rennes, 35000, Rennes, France

    Pascal Guggenbuhl

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  1. Simon Cadiou
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Cadiou, S., Coiffier, G., Jouneau, S. et al. Sacroiliac joint in sarcoidosis on computed tomography: a monocentric retrospective study (SISTER). Rheumatol Int 42, 431–440 (2022). https://doi.org/10.1007/s00296-021-05021-z

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