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Resilience in women with primary Sjögren’s syndrome

  • Observational Research
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Abstract

To assess the relationship between resilience and several diseases and individual features in primary Sjӧgren's Syndrome (SS) patients. Resilience was assessed using the Resilience Scale (RS-14). Disease activity, damage, and reported symptoms were assessed by means of ESSDAI (EULAR Sjögren's syndrome disease activity index), SSDDI (Sjӧgren's Syndrome Disease Damage Index) and ESSPRI (EULAR Sjӧgren's Syndrome Patient Reported Index). EuroQol, HADS (Hospital Anxiety and Depression Scale), SF-12 (Short-form 12 health survey), FAS (Fatigue Assessment Scale), FACIT-F (Functional Assessment of Chronic Illness Therapy – Fatigue), and IPAQ (International Physical Activity Questionnaire) questionnaires were submitted to evaluate physical and mental well-being of the recruited patients. Data about the autoimmune profile, systemic manifestations, and current therapy were collected. Educational qualifications and work activities were also considered. Descriptive, correlational, and linear regression analysis were performed. 74 consecutive women with primary SS and 74 sex and age-matched healthy subjects as a control group were recruited. SS patients displayed a moderate value of resilience (median 78.5) with no significant difference compared to controls (p = 0.38). An inverse relationship was found between resilience and mood disorders such as anxiety (p = 0.038) and depression (p < 0.001). Greater resilience was associated with a better perception of the quality of life (p = 0.02) and general health (p < 0.001), as well as with less fatigue (p = 0.008) and a more physically active lifestyle (p = 0.001). No significant relationship was found neither between resilience and age, socio-demographic and disease characteristics, nor with ESSDAI (p = 0.26), ESSPRI (p = 0.83) and SSDDI (p = 0.67). This is the first study assessing resilience in a large group of unselected primary SS patients. Most resilient primary SS patients are less depressed and show a better perception of their health. Greater resilience tends to correlate with less anxiety, physical and mental fatigue, and a more active lifestyle, while no association with disease activity and duration, damage, and socio-demographic features was detected. Considering the well-known role of resilience in helping to better cope with chronic illnesses, its assessment in SS patients should not be overlooked and the possible strategies for its improvement should be better explored and further implemented.

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Acknowledgements

The authors declare that the article has not been published and is not under consideration for publication elsewhere. The manuscript has been read and approved by all of the authors.

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Authors and Affiliations

  1. Department of Clinical, Internal, Anesthetic and Cardiovascular Science-Rheumatology Unit, Azienda Ospedaliera Universitaria Policlinico Umberto I, Sapienza University of Rome, viale del Policlinico 155, 00161, Rome, Italy

    Roberta Priori, Federico Giardina, Raffaella Izzo, Angelica Gattamelata & Serena Colafrancesco

  2. Department of Oral and Maxillo-Facial Surgery, Sapienza University of Rome, Rome, Italy

    Massimo Fusconi

  3. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy

    Giuseppe Curcio

  4. UniCamillus, Saint Camillus International University of Health Sciences, 00131, Rome, Italy

    Roberta Priori

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  1. Roberta Priori
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AG, SC, RI collected data. GC made the statistical analysis. FG and RP drafted the manuscript. RP and GC revised the manuscript.

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Correspondence to Roberta Priori.

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Priori, R., Giardina, F., Izzo, R. et al. Resilience in women with primary Sjögren’s syndrome. Rheumatol Int 41, 1987–1994 (2021). https://doi.org/10.1007/s00296-021-04899-z

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