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Is Henoch–Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?

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Abstract

Henoch–Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role. We aimed to clarify whether HSP predisposes to FGIDs in pediatric population. Seventy-four children with HSP, diagnosed at least 6 months before the study and 78 healthy controls were enrolled to the study. Patients with red flag signs for organic GI disorders were excluded. Rome IV criteria were utilized for FGIDs diagnosis. We compared the frequencies of FGIDs between HSP patients and healthy subjects. We also examined the parameters including age, abdominal pain, arthralgia, bloody stool, renal involvement and treatment with corticosteroids and laboratory results at HSP diagnosis such as erythrocyte sedimentation rate, C-reactive protein, hemoglobin, leukocytes and platelet counts among patients with and without FGIDs. Overall FGIDs and IBS frequency were 35.1% (n = 26) and 10.8% (n = 8) in HSP patients, 19.2% (n = 15) and 2.6% (n = 2) in healthy controls, respectively. Disease characteristics and laboratory parameters at disease onset were similar between HSP patients with and without FGIDs. Overall FGIDs rate, particularly IBS were statistically higher in HSP patients. We speculate that children with preceding HSP may be predisposed to FGIDs. Since the FGIDs pathogenesis is still remains unclear, further studies are needed to confirm this hypothesis and clarify the etiology. Physicians also should pay attention to FGIDs in HSP patients with ongoing abdominal pain and thus prevent this comorbidity with dietary and psychologic measures.

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Authors and Affiliations

  1. Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Adana, Turkey

    Rabia Miray Kisla Ekinci, Sibel Balcı & Mustafa Yilmaz

  2. Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey

    Okkes Ozgur Mart & Halil Celik

  3. Department of Pediatric Gastroenterology, Cukurova University Faculty of Medicine, Adana, Turkey

    Gokhan Tumgor & Sibel Yavuz

  4. Department of Pediatric Allergy and Immunology, Cukurova University Faculty of Medicine, Adana, Turkey

    Dilek Dogruel & Derya Ufuk Altintas

Authors
  1. Rabia Miray Kisla Ekinci
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  2. Sibel Balcı
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  3. Okkes Ozgur Mart
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  4. Gokhan Tumgor
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Contributions

Dr. RMKE and Dr. MY conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Dr. SB, Dr. GT, Dr. SY and Dr. DD collected data, carried out the initial analyses, and reviewed and revised the manuscript. Dr. DUA, Dr. OOM and Dr. HC designed the data collection instruments, and coordinated and supervised data collection, and critically reviewed the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Rabia Miray Kisla Ekinci.

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Authors Rabia Miray Kisla Ekinci, Sibel Balci, Okkes Ozgur Mart, Gokhan Tumgor, Sibel Yavuz, Halil Celik, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz declare that they have no conflicts of interest.

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Kisla Ekinci, R.M., Balcı, S., Mart, O.O. et al. Is Henoch–Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?. Rheumatol Int 39, 317–322 (2019). https://doi.org/10.1007/s00296-018-4129-7

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  • DOI: https://doi.org/10.1007/s00296-018-4129-7

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