Skip to main content

Advertisement

Log in

Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy

  • Cases with a Message
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

We describe the case of a 32-year-old male with previous history of subacute cutaneous lupus erythematosus (SCLE) who presented with arthritis followed by a unilateral lower-limb sensorimotor impairment, without biochemical or immunological marker abnormalities. Our patient currently satisfies only three of the systemic lupus international collaborating clinics criteria. Management of such patients is challenging due to lack of examples in the literature, with this case being the first described where a seronegative patient with SCLE demonstrated neurological involvement. A brief review of the available literature is included.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Petri M, Orbai AM, Alarcón GS et al (2012) Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64:2677–2686

    Article  PubMed  PubMed Central  Google Scholar 

  2. Grönhagen CM, Fored CM, Granath F, Nyberg F (2011) Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden. Br J Dermatol 164:1335–1341

    Article  PubMed  Google Scholar 

  3. Grönhagen CM, Nyberg F (2014) Cutaneous lupus erythematosus: an update. Indian Dermatol Online J 5:7–13

    Article  PubMed  PubMed Central  Google Scholar 

  4. Oomatia A, Fang H, Petri M, Birnbaum J (2014) Peripheral neuropathies in systemic lupus erythematosus: clinical features, disease associations, and immunologic characteristics evaluated over a twenty-five-year study period. Arthritis Rheumatol 66:1000–1009

    Article  CAS  PubMed  Google Scholar 

  5. Doherty SD, Hsu S (2008) A case series of 48 patients treated with thalidomide. J Drugs Dermatol 7:769–773

    PubMed  Google Scholar 

  6. Mancano MA (2015) Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; beta blocker use, hypertension, and the risk of psoriasis: eczematous reaction to intravenous immunoglobulin: Nicolau syndrome after intra-articular glucocorticoid injection: troponin leak associated with drug-induced methemoglobinemia. Hosp Pharm 50:13–17

    Article  PubMed  PubMed Central  Google Scholar 

  7. Anyanwu CO, Stewart CL, Werth VP (2014) Thalidomide-induced orofacial neuropathy. J Clin Rheumatol 20:399–400

    PubMed  PubMed Central  Google Scholar 

  8. Jasmin R, Sockalingam S, Ramanaidu LP, Goh KJ (2015) Clinical and electrophysiological characteristics of symmetric polyneuropathy in a cohort of systemic lupus erythematosus patients. Lupus 24:248–255

    Article  CAS  PubMed  Google Scholar 

  9. Fierro B, Brighina F, Amico L et al (1999) Evoked potential study and radiological findings in patients with systemic lupus erythematosus. Electromyogr Clin Neurophysiol 39:305–313

    CAS  PubMed  Google Scholar 

  10. Blaes F (2015) Diagnosis and therapeutic options for peripheral vasculitic neuropathy. Ther Adv Musculoskelet Dis 7:45–55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yildiz OK, Balaban H, Senel S, Cevik S (2011) Acute lumbosacral polyradiculoneuropathy heralding transformation to systemic lupus erythematosus in a patient with discoid lupus. Lupus 20:972–974

    Article  CAS  PubMed  Google Scholar 

  12. Levy Y, Uziel Y, Zandman G et al (2005) Response of vasculitic peripheral neuropathy to intravenous immunoglobulin. Ann NY Acad Sci 1051:779–786

    Article  CAS  PubMed  Google Scholar 

  13. Martinez-Taboada VM, Alonso RB, Armona J, Fernandez-Sueiro JL, Gonzalez Vela C, Rodriguez-Valverde V (1996) Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. Lupus 5:74–76

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank our patient for his consent to publish his case and the related pictures. The authors would also like to thank Dr Maria Hatzikosti (NGH Radiology Department) for her guidance and Prof Boumpas Dimitrios (University of Athens) for his guidance and review of this manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fanourios Georgiades.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the individual included in this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Psarelis, S., Georgiades, F., Ioannou, A. et al. Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. Rheumatol Int 37, 831–835 (2017). https://doi.org/10.1007/s00296-016-3611-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-016-3611-3

Keywords

Navigation