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Risk of ischemic stroke in patients with polymyositis and dermatomyositis: a systematic review and meta-analysis

  • Original Article - Observational Research
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Abstract

Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been demonstrated to increase ischemic stroke risk, but the data on polymyositis (PM) and dermatomyositis (DM) remain unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing ischemic risk in patients with PM/DM versus non-PM/DM participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Three cohort studies were identified and included in our data analysis. The pooled risk ratio of ischemic stroke in patients with PM/DM was 1.61 (95 % CI 1.28–2.02). The statistical heterogeneity of this meta-analysis was insignificant with an I 2 of 0 %. Our study demonstrated a statistically significant increased ischemic stroke risk among patients with PM/DM.

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Conflict of interest

We do not have any financial or non-financial potential conflicts of interest.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Patompong Ungprasert

  2. Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Wisit Cheungpasitporn & Charat Thongprayoon

  3. Cardiac Electrophysiology Unit, Department of Physiology, and Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Karn Wijarnpreecha

  4. Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Wasin Ahuja

  5. Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Praveen Ratanasrimetha

Authors
  1. Patompong Ungprasert
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  2. Wisit Cheungpasitporn
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  3. Karn Wijarnpreecha
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  4. Wasin Ahuja
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  5. Praveen Ratanasrimetha
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  6. Charat Thongprayoon
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Corresponding author

Correspondence to Patompong Ungprasert.

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Ungprasert, P., Cheungpasitporn, W., Wijarnpreecha, K. et al. Risk of ischemic stroke in patients with polymyositis and dermatomyositis: a systematic review and meta-analysis. Rheumatol Int 35, 905–909 (2015). https://doi.org/10.1007/s00296-014-3166-0

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  • DOI: https://doi.org/10.1007/s00296-014-3166-0

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