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Spindle pole power in health and disease

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Abstract

Saccharomyces cerevisiae has been widely used as a model system for the study of basic biological processes which are usually evolutionarily conserved from yeasts to multicellular eukaryotes. These studies are very important because they shed light on mechanisms that are altered in human diseases and help the development of new biomarkers and therapies. The mitotic spindle is a conserved apparatus that governs chromosome segregation during mitosis. Given its crucial role for genome stability and, therefore, for cell viability, its structure and function are strictly regulated. Recent findings reveal new levels of regulation in mitotic spindle dynamics and link spindle pole diversification with cell fate determination, health, disease and aging.

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Acknowledgements

R. F. researches are supported by Grants from PRIN (Progetti di Ricerca di Interesse Nazionale) and from the University of Milano Bicocca (FA). E. R. is supported by a fellowship from the Associazione Italiana per Ricerca sul Cancro (AIRC), Love Design Rif: 18196.

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Author notes

  1. Erica Raspelli

    Present address: IFOM-Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy

Authors and Affiliations

  1. Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy

    Erica Raspelli & Roberta Fraschini

Authors
  1. Erica Raspelli
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  2. Roberta Fraschini
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Correspondence to Roberta Fraschini.

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Communicated by M. Kupiec.

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Raspelli, E., Fraschini, R. Spindle pole power in health and disease. Curr Genet 65, 851–855 (2019). https://doi.org/10.1007/s00294-019-00941-7

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