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Two 3D supramolecular complexes: photoluminescent property and therapeutic effect with synergistic curcumin on post-stroke depression

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Abstract

Coordination polymers have been a hot research topic in the field of biomedicine for their interesting bioactivities. To study the effects of metal ions on the bioactivity of the resulting coordination polymers, in this study, two novel coordination polymers, [Zn4(L)4(bix)4]·n(DMF)·4n(H2O) (1) and [Cd(L)(bix)(H2O)2]n·2n(H2O) (2) (H2L = 5-(1-oxoisoindolin-2-yl)isophthalic acid, bix = 5-(1-oxoisoindolin-2-yl)isophthalic acid, DMF =  N,N′-dimethylformide), have been synthesized by the reactions of H2L, bix and Zn(II) or Cd(II) salts under the solvothermal condition and further characterized via the single crystal X-ray diffraction, powder X-ray diffraction, elemental analysis and thermogravimetric analyses. The CIE chromaticity diagram indicated that complexes 1 and 2 are excellent blue luminescent materials. Their therapeutic effect with synergistic curcumin on post-stroke depression was explored in the present work. First of all, the analysis of enzyme-linked immunosorbent assay was exploited for testing the 5-hydroxytryptamine (5-HT) content exists in brain. Next, the serotonin transporter relative expression was also analyzed with the detection of real-time reverse transcription-polymerase chain reaction (RT-PCR). The experimental results show that the CP 1 could be a better candidate for synergistic curcumin for treating post-stroke depression by increasing 5-HT content and relative expression of serotonin transporter than CP 2.

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Data availability

Selected bond lengths (Å) and angles (°) for 1–2 (Table S1); the detailed hydrogen bond parameters for 2 (Table S2); The PXRD patterns (a) for 1 and (b) for 2 (Fig. S1), the information could be found in the supporting information file.

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Authors and Affiliations

  1. Rehabilitation Medicine Department, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, China

    Xin Zhao, Qiang Dong & Meng-Yan Ji

  2. Neurosurgery Department, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, China

    Lian-Feng Dang

  3. Department of Medicine, Shanghai University, Shanghai, China

    Ye Gao & Bing Jiang

Authors
  1. Xin Zhao
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  2. Qiang Dong
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  3. Meng-Yan Ji
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  4. Lian-Feng Dang
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  5. Ye Gao
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  6. Bing Jiang
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Correspondence to Lian-Feng Dang.

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Zhao, X., Dong, Q., Ji, MY. et al. Two 3D supramolecular complexes: photoluminescent property and therapeutic effect with synergistic curcumin on post-stroke depression. Polym. Bull. 80, 7791–7803 (2023). https://doi.org/10.1007/s00289-022-04421-w

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  • DOI: https://doi.org/10.1007/s00289-022-04421-w

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