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A novel microwave-assisted synthesis, characterization and evaluation of luliconazole-loaded solid lipid nanoparticles

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Abstract

The aim of the present investigation is to use microwave-assisted technique to produce luliconazole-loaded solid lipid nanoparticles using stearic acid and Pluronic F-68. The effect of microwave power and concentration of Pluronic F-68 on particle size and zeta potential was studied employing response surface methodology. The response surface models indicated that microwave power has greater influence on particle size and zeta potential than the effect of Pluronic F-68 concentration. However, microwave power and Pluronic F-68 concentration have no significant influence on the entrapment of luliconazole in solid lipid nanoparticles. The solid lipid nanoparticles produced were characterized for particle size and zeta potential by dynamic light scattering, entrapment efficiency and transmission electron microscopy. The particle size and zeta potential of optimized batch were estimated to be 91.39 nm and −20.1 mV, respectively. The solid lipid nanoparticles exhibited high entrapment efficiency (96.68%) for luliconazole. The solid lipid nanoparticles showed 100% release of luliconazole with in 24 h at pH 7.4 following Higuchi’s square root kinetics with diffusion through the matrix being primary release mechanism. The transmission electron microscopy unveiled the spherical shape of solid lipid nanoparticles. The solid lipid nanoparticles were also evaluated for antifungal activity against Candida albicans (MTCC 227) and Aspergillus niger (MTCC 8189). The solid lipid nanoparticles exhibited excellent antifungal action with minimum inhibitory concentration of 6.25 µg/mL against Candida albicans (MTCC 227) and 12.5 µg/mL against Aspergillus niger (MTCC 8189).

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Acknowledgement

The authors express gratitude to Department of Science and Technology, Government of India, for providing financial assistance to Jyoti Mundlia under DST-PURSE Programme.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, 125001, India

    Manisha Sharma, Jyoti Mundlia, Tarun Kumar & Munish Ahuja

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  1. Manisha Sharma
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  2. Jyoti Mundlia
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Correspondence to Munish Ahuja.

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Sharma, M., Mundlia, J., Kumar, T. et al. A novel microwave-assisted synthesis, characterization and evaluation of luliconazole-loaded solid lipid nanoparticles. Polym. Bull. 78, 2553–2567 (2021). https://doi.org/10.1007/s00289-020-03220-5

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