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Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel

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Abstract

In this manuscript, the novel sodium alginate-g-poly [acrylic acid–N-(3-dimethylaminopropyl) methyl acrylamide] [NaAlg-g-P(AA-co-DMAPMA)] hydrogel was prepared using free radical polymerization. Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), point zero charge and scanning electron microscopy were used to investigate the structure, thermal stability, surface charge and microstructure of the hydrogel. The factors that affected the swelling ratio of the hydrogel were investigated in detail, such as pH and ionic strength; the results showed that the hydrogel has a favorable pH-sensitive property. To investigate drug loading and sustained release of NaAlg-g-P(AA-co-DMAPMA), rhodamine B as a model drug was loaded on NaAlg-g-P(AA-co-DMAPMA). The in vitro drug release study conducted at pH 1.86 and 6.86 shows that NaAlg-g-P(AA-co-DMAPMA) was suitable for colon-specific drug delivery systems.

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Acknowledgments

This work has been supported by the Youthful National Science Foundation of Hubei (No. 2014CFB618); the Open Science Foundation of Key Laboratory of Biological Resources Protection and Utilization of Hubei Province (No. PKLHB1511); the Science Research Group of Hubei University for Nationalities (MY2014T007, MY2013T004); the Doctoral Science Research Foundation of Hubei University for Nationalities (MY2013B017).

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Authors and Affiliations

  1. Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi, Hubei, 445000, China

    Chengyi Wu

  2. Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi, Hubei, 445000, China

    Chengyi Wu, Dandan Wang, Huimin Wu & Youmeng Dan

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  1. Chengyi Wu
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  2. Dandan Wang
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  3. Huimin Wu
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Correspondence to Chengyi Wu.

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Wu, C., Wang, D., Wu, H. et al. Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel. Polym. Bull. 73, 3255–3269 (2016). https://doi.org/10.1007/s00289-016-1653-z

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  • DOI: https://doi.org/10.1007/s00289-016-1653-z

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