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Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6

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Abstract

Investigation of an antimicrobial and cytotoxic ethyl acetate extract prepared from solid fermentation of the marine-derived fungus Penicillium citrinum VM6 led to the isolation of eight metabolites (1–8), including one citrinin dimer dicitrinone F (1). Of these, compound 7 was isolated for the first time from the Penicillium genus and compound 1 with carbon-bridged C-7/C-7’ linkage is rarely reported. All compounds (1–8) exhibited selective antimicrobial activity against the tested Gram-positive bacteria and Candida albicans with MICs of 32–256 µg/mL. Compounds 1 and 8 exhibited cytotoxicity against all tested cell lines A549, MCF7, MDA-MB-231, Hela, and AGS with IC50 values of 6.7 ± 0.2 to 29.6 ± 2.2 µg/mL, whereas compound 5 had selective cytotoxicity against the MCF7 cell lines with IC50 of 98.1 ± 7.8 µg/mL.

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Funding

This research was funded by the Vietnam Academy of Science and Technology under grant number: VAST06.03/22–23.

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Authors and Affiliations

  1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

    Nguyen Mai Anh, Vu Thi Thu Huyen, Vu Thi Quyen, Phi Thi Dao, Do Thi Quynh, Doan Thi Mai Huong, Pham Van Cuong & Le Thi Hong Minh

  2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

    Nguyen Mai Anh, Doan Thi Mai Huong & Pham Van Cuong

  3. Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Thua Thien Hue, Vietnam

    Ton That Huu Dat

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Contributions

All authors contributed to the study’s conception and design. Material preparation, data collection and analysis were performed by NMA, VTTH, VTQ, PTD, DTQ, DTMH, PVC, TTHD, and LTHM. The first draft of the manuscript was written by TTHD and LTHM. All authors read and approved the final manuscript.

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Correspondence to Ton That Huu Dat or Le Thi Hong Minh.

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Anh, N.M., Huyen, V.T.T., Quyen, V.T. et al. Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6. Curr Microbiol 81, 32 (2024). https://doi.org/10.1007/s00284-023-03568-7

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