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Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells

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Abstract

Adenosine 5′-triphosphate (ATP) is released from dying or damaged cells, as well as from activated cells. Once secreted, extracellular ATP induces several immune responses via P2X and P2Y receptors. Basophils and mast cells release ATP upon FcεRI-crosslinking, and ATP activates basophils and mast cells in an autocrine manner. Nucleotide-converting ectoenzymes, such as E-NTPD1, E-NTPD7, and E-NPP3, inhibit ATP-dependent immune responses by hydrolyzing ATP, thereby contributing to immune response regulation. E-NPP3 is a well-known activation marker for human basophils. E-NPP3’s physiologic function has recently been disclosed in mice. E-NPP3 is rapidly induced on basophils and mast cells after FcεRI-crosslinking and hydrolyzes extracellular ATP on cell surfaces to prevent ATP-dependent excess activation of basophils and mast cells. In the absence of E-NPP3, basophils and mast cells are overactivated and mice suffer from severe chronic allergic inflammation. Thus, the ATP-hydrolyzing ectoenzymes E-NPP3 has a nonnegligible role in the regulation of basophil- and mast cell-mediated allergic responses.

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Acknowledgments

We thank C. Hidaka for secretarial assistance. This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan Agency for Medical Research and Development, and the Ministry of Health, Labour and Welfare.

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Authors and Affiliations

  1. Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, 565-0871, Japan

    Shih Han Tsai & Kiyoshi Takeda

  2. Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, 100-0004, Japan

    Kiyoshi Takeda

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  1. Shih Han Tsai
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  2. Kiyoshi Takeda
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Correspondence to Kiyoshi Takeda.

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This article is a contribution to the special issue on Basophils and Mast Cells in Immunity and Inflammation - Guest Editor: Hajime Karasuyama

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Tsai, S.H., Takeda, K. Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells. Semin Immunopathol 38, 571–579 (2016). https://doi.org/10.1007/s00281-016-0564-2

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  • DOI: https://doi.org/10.1007/s00281-016-0564-2

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