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Mirvetuximab soravtansine in ovarian cancer therapy: expert opinion on pharmacological considerations

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Abstract

ImmunoGen developed mirvetuximab soravtansine as an antibody–drug conjugate comprising of a humanized anti-folate receptor—α (FRα) monoclonal antibody of IgG1k subtype, a cleavable linker, and a cytotoxic payload, DM4. Mirvetuximab soravtansine was granted accelerated approval by the US FDA on November 14, 2022, for the treatment of adult patients with FRα positive, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer who have received 1—3 prior systemic treatment regimens. The approval of mirvetuximab soravtansine represents a breakthrough for addressing the unmet medical needs of ovarian cancer, especially for up to 80% of patients who relapse and become resistant to platinum-based chemotherapy, resulting in poor prognosis and limited treatment options. However, it is my impression that addressing several pharmacological factors could improve the safety and efficacy of mirvetuximab soravtansine. This article summarizes the current pharmacological profile of mirvetuximab soravtansine and provides an expert opinion on pharmacological strategies for optimizing its safety and efficacy profile for the treatment of platinum-resistant ovarian cancer.

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Fig. 1

Adapted from Joubert, N et al., [4]. © 2020 Joubert, N et al., Distributed under a Creative Commons Attribution CC BY licence

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Funding

CKN is a recipient of the Canadian Institutes of Health Research Doctoral Scholarship, Canadian Institutes of Health Research Doctoral Scholarship—Michael Smith Foreign Study Supplements Award, Ontario Graduate Scholarship, Pfizer Canada Graduate Fellowship, and Leslie Dan Faculty of Pharmacy Dean’s Fellowship.

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  1. OneDrug, Toronto, ON, Canada

    Chukwunonso K. Nwabufo

  2. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada

    Chukwunonso K. Nwabufo

  3. Program in Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada

    Chukwunonso K. Nwabufo

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Nwabufo, C.K. Mirvetuximab soravtansine in ovarian cancer therapy: expert opinion on pharmacological considerations. Cancer Chemother Pharmacol 93, 89–105 (2024). https://doi.org/10.1007/s00280-023-04575-y

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