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Efficacy and safety of liposome-paclitaxel and carboplatin based concurrent chemoradiotherapy for locally advanced lung squamous cell carcinoma

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Abstract

Objective

The aim of this study was to evaluate the efficacy and toxicities of liposome-paclitaxel and carboplatin concurrent with radiotherapy for locally advanced lung squamous cell carcinoma (LSCC).

Methods

The clinical data of 38 patients with locally advanced LSCC treated with liposome-paclitaxel based concurrent chemoradiotherapy were collected and reviewed. The overall response, toxicities, progression-free survival and overall survival were analyzed with SPSS software.

Result

The efficacy of treatment was classified as complete remission in 4 cases (10.5%), partial remission in 22 cases (57.9%) and stable disease in 12 cases (31.6%). The objective response rate was 68.4% (26/38). The most common types of hematological toxicities were anemia (65.7%) and leukopenia (57.9%), but all the events were transient. No paclitaxel-induced allergic reactions occurred during the treatment. The median PFS and OS time were 17.0 and 29.0 months.

Conclusions

Liposome-paclitaxel and carboplatin concurrent with radiotherapy showed a significant antitumor effect to LSCC with manageable toxicities. Further clinical investigation are warranted to evaluate the efficacy of this regimen.

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Acknowledgements

We are grateful to the patients who are included in this study. This study was supported by grants from the Nature Science Foundation of Zhejiang Province (No. LY14H160012).

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Authors and Affiliations

  1. Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

    Guofu Chen, Liming Sheng & Xianghui Du

  2. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, 1 Banshandong Road, Hangzhou, 310022, Zhejiang, China

    Guofu Chen, Liming Sheng & Xianghui Du

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  1. Guofu Chen
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  2. Liming Sheng
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Correspondence to Liming Sheng or Xianghui Du.

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Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Chen, G., Sheng, L. & Du, X. Efficacy and safety of liposome-paclitaxel and carboplatin based concurrent chemoradiotherapy for locally advanced lung squamous cell carcinoma. Cancer Chemother Pharmacol 82, 505–510 (2018). https://doi.org/10.1007/s00280-018-3640-6

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  • DOI: https://doi.org/10.1007/s00280-018-3640-6

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