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Treatment of primary cardiac diffuse large B-cell lymphoma involving the coronary sinus with R-EPOCH: a case report and literature review

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Abstract

Primary cardiac lymphomas (PCLs) are a rare clinical entity, in which treatment guidelines remain to be established. Rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH) has been proposed, given that it involves a continuous infusion of anthracycline, reducing the risk of a cardiotoxicity and therefore the theoretical risk of perforation. However, the literature on this method of treatment is scarce. Herein, we present a unique case of a 75-year-old male, diagnosed with primary cardiac diffuse large B-cell lymphoma (DLBCL) with relatively unusual involvement of the coronary sinus, treated first with one cycle of R-EPOCH, followed by three cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) to reduce said risk. To our knowledge, this is one of two cases, in which a patient with PCL was treated this way.

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Authors and Affiliations

  1. Texas A&M Health Science Center, School of Medicine, Bryan, TX, 77807, USA

    Aryan Rezvani

  2. Houston Methodist Hospital, Dr. Mary and Ron Neal Cancer Center, Houston, TX, 77030, USA

    Shilpan Shah

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  1. Aryan Rezvani
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  2. Shilpan Shah
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A.R. wrote the main manuscript of the text. S.S. provided guidance to A.R. and reviewed/revised the manuscript critically.

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Correspondence to Aryan Rezvani.

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Rezvani, A., Shah, S. Treatment of primary cardiac diffuse large B-cell lymphoma involving the coronary sinus with R-EPOCH: a case report and literature review. Ann Hematol (2024). https://doi.org/10.1007/s00277-024-05793-x

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