Abstract
To report the clinical results after definitive radiotherapy (RT) for indolent primary cutaneous B cell lymphoma (pcBCL). The data concerning all patients treated for indolent pcBCL with RT with a curative intent between 1992 and 2012 were reviewed. All cases were (re)classified according to the World Health Organization (WHO) guidelines. A total of 42 patients with biopsy-proven primary cutaneous follicle center lymphoma (pcFCL) and primary cutaneous marginal zone lymphoma (pcMZL) were included. The median follow-up is 9.5 years. Treatment with RT resulted in complete response (CR) in all patients. Eight patients showed one or multiple relapses confined to the skin. No in-field recurrences were observed. For the entire cohort, the 10-year relapse-free survival (RFS) and overall survival (OS) were 71.1% and 87.1%, respectively. Univariate (UA) and multivariate (MA) analysis revealed extra-trunk primary lesion (MA) and multiple lesions (UA) as unfavorable prognostic factors. The 5-year RFS rate for patients with trunk lesion was 89.4% versus 66.9% for those with other location (p = 0.02). The 5-year RFS rates were 83.5 and 57.1% in case of single and multiple lesions (p = 0.04). An excellent survival can be achieved with definitive RT in indolent pcBCL. Patients with multiple and extra-trunk primary cutaneous lesions probably warrants intensification of therapy. Prospective studies are mandatory.
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Author Francesca De Felice declares that she has no conflict of interest. Author Lavinia Grapulin declares that she has no conflict of interest. Author Alessandra Pieroni declares that she has no conflict of interest. Author Francesca Salerno declares that she has no conflict of interest. Author Gianna Maria D’Elia declares that she has no conflict of interest. Author Alessandro Pulsoni declares that he has no conflict of interest. Author Daniela Musio declares that she has no conflict of interest. Author Vincenzo Tombolini declares that he has no conflict of interest.
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De Felice, F., Grapulin, L., Pieroni, A. et al. Radiation therapy in indolent primary cutaneous B cell lymphoma: a single institute experience. Ann Hematol 97, 2411–2416 (2018). https://doi.org/10.1007/s00277-018-3471-x
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DOI: https://doi.org/10.1007/s00277-018-3471-x