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A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation

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Abstract

Taste disorders are one of the most common complications in patients undergoing allogeneic hematopoietic cell transplantation (HCT). They persist in some patients as a late complication 3 months or more after HCT. Therefore, we conducted a cross-sectional study to evaluate the prevalence and predictive factors of late taste disorders, with the help of a self-reporting and closed-ended questionnaire, which was distributed among 91 patients in our institute. The median age at this study was 50 (range, 25–69) years. The median follow-up period was 54 (range, 3–234) months after HCT. Taste disorders were observed in 43 patients (47%). The most frequent form of late taste disorders was reduced appetite in 18 patients (20%). The most frequent form of decline of basic taste was umami, which was observed in 12 patients (13%). Almost all taste disorders were mild in their severity. Multivariate logistic regression analyses showed that the duration of less than 1 year post HCT and the presence of oral chronic graft-versus-host disease are important risk factors for late taste disorders in survivors of HCT. These data suggested that taste disorders usually return to normal levels more than a year after HCT in most recipients.

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Acknowledgements

The authors thank all of the physicians and staff at the hospital for their help in this study.

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Authors and Affiliations

  1. Department of Nursing, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Tomoko Sato, Yoriko Miwa, Nozomi Sugihara, Yukari Tsuru, Hatsuko Narita, Satomi Kiriyama & Koji Kobayashi

  2. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Takaaki Konuma, Seiko Kato, Maki Oiwa-Monna, Satoshi Takahashi & Arinobu Tojo

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  1. Tomoko Sato
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  2. Takaaki Konuma
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  3. Yoriko Miwa
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  4. Nozomi Sugihara
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  5. Yukari Tsuru
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  9. Maki Oiwa-Monna
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  10. Koji Kobayashi
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  11. Satoshi Takahashi
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Corresponding author

Correspondence to Takaaki Konuma.

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The authors declare no competing financial interests.

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Sato, T., Konuma, T., Miwa, Y. et al. A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation. Ann Hematol 96, 1841–1847 (2017). https://doi.org/10.1007/s00277-017-3087-6

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  • DOI: https://doi.org/10.1007/s00277-017-3087-6

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