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Safety and Oncologic Outcomes of Percutaneous Cryoablation of Renal Cell Carcinoma Recurrences in the Ipsilateral Kidney Following Partial Nephrectomy

  • Clinical Investigation
  • lnterventional Oncology
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To retrospectively investigate the safety and oncological outcomes of cryoablation performed on residual/recurring renal cell carcinoma (RCC) in the ipsilateral kidney following partial nephrectomy (PN).

Materials and Methods

Data dealing with patients’, RCC, procedure (including the length of the hospital stay), and follow-up (technical efficacy [TE], local tumor progression-free survival [LTPFS], disease-free survival [DFS], metastasis-free survival [MFS], cancer-specific survival (CSS), and overall survival [OS]) were retrospectively collected and analyzed.

Results

Between January 2008 and November 2020, 21 consecutive patients (17 [81%] men; 4 [19%] women; median age 68 years; range 43–82) underwent cryoablation due to residual/recurring RCC in the PN site (15 patients) or de-novo RCC (6 patients) in the ipsilateral kidney.

Median tumor size was 2.2 cm (mean 2.3 cm; range 0.8–4; interquartile range [IQR] 1.9–3). There were two (2/21; 10%) minor self-limiting hemorrhagic complications, both occurring in the group of patients with RCC in the PN site. Median hospital stay was 2 days (mean 2.1; range 1–5; IQR 2–2).

TE was 100% (21/21 patients), and 10-year estimates of LTPFS, MFS and DFS were 74.1% (95% confidence intervals [CI] 56.8–96.7%), 36.4% (95% CI 14.2–93.8%), and 43.5% (95% CI 21.9–86.4%), respectively. CSS and OS were 100% at the last available follow-up (median 56 months; mean 67.4; range: 12–147; IQR:34–95).

Conclusion

Cryoablation in patients with residual/recurring RCC following PN is safe and results in high 10-year estimates of LTPFS.

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Abbreviations

PN:

Partial Nephrectomy

RCC:

Renal Cell Carcinoma

CT:

Computed Tomography

MRI:

Magnetic Resonance Imaging

ISUP:

Society of Urologic Pathologists

LTPFS:

Local Tumor Progression-Free Survival

DFS:

Disease-free survival

MFS:

Metastasis-Free Survival

CSS:

Cancer-Specific Survival

OS:

Overall Survival

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Authors and Affiliations

  1. Department of Imaging, Service d’Imagerie, Lyon Sud Hospital, University Hospital of Lyon, Hospices Civils de Lyon, Lyon, France

    Julien Rossi

  2. Claude-Bernard University of Lyon, 165 chemin du Grand Revoyet, 69495, Pierre-Bénite, Lyon, France

    Julien Rossi

  3. Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France

    Roberto Luigi Cazzato, Pierre de Marini, Pierre Auloge, Pierre-Alexis Autrusseau, Julien Garnon & Afshin Gangi

  4. Department of Medical Oncology, Strasbourg-Europe Cancer Institute (ICANS), Strasbourg, France

    Roberto Luigi Cazzato

  5. Epsom and St Helier University Hospitals, London, UK

    Danoob Dalili & Hervé Lang

  6. Department of Urology, University Hospital of Strasbourg, Strasbourg, France

    Thibault Tricard & Baptiste Poussot

  7. School of Biomedical Engineering and Imaging Sciences, King’s College London, Strand, WC2R 2LS, London, UK

    Afshin Gangi

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  1. Julien Rossi
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Correspondence to Julien Rossi.

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Afshin Gangi and Julien Garnon, are consultants for Galil Medical Ltd. Other authors declare that they have no conflict of interest.

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Rossi, J., Cazzato, R.L., de Marini, P. et al. Safety and Oncologic Outcomes of Percutaneous Cryoablation of Renal Cell Carcinoma Recurrences in the Ipsilateral Kidney Following Partial Nephrectomy. Cardiovasc Intervent Radiol 45, 656–664 (2022). https://doi.org/10.1007/s00270-022-03079-1

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