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External Validation of the Renal Ablation-Specific (MC)2 Risk Scoring System in Predicting Complications from Percutaneous Renal Cryoablation

  • Clinical Investigation
  • Non-Vascular Interventions
  • Published:
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Abstract

Purpose

The (MC)2 score is a renal ablation-specific risk scoring system to predict major complications from percutaneous renal cryoablation (PRCA). However, it is untested in an external population of patients. The purpose of this study is to validate the ability of the (MC)2 score to predict major complications after PRCA in an external population.

Materials and Methods

Retrospective review of patients who underwent PRCA from 2004 to 2019. Patient demographics, medical histories, and tumor characteristics were collected. The (MC)2 score was calculated and patients were assigned to low risk (< 5), moderate risk (5–8) and high-risk (> 8) groups. Complications were recorded. Major complications were classified according to CIRSE guidelines.

Results

Two hundred and one patients [M = 116; F = 85; median age = 65 (range 27–90)] met inclusion criteria. Eleven patients (5.5%) developed major complications and 50 patients (24.9%) developed minor complications. Of patients with major complications, mean tumor diameter was 39 mm (± 10.4), seven patients (63.6%) had a central tumor, four patients (36.4%) had complicated diabetes, and one patient (9.1%) had a prior MI. Major complication rates were 2.1%, 14%, and 14.3% in the (MC)2 low risk, moderate risk, and high risk groups, respectively. The mean (MC)2 score for patients with major complications [6.2 (± 2.4)] was higher than the mean score for patients with minor complications [4.7 (± 2.4) (p = 0.07)] and no complications [3.9 (± 1.9) (p < 0.01)]. The area under the ROC curve to predict major complications was 0.78.

Conclusion

The (MC)2 risk scoring system appropriately identifies patients at risk for major complications from PRCA in this external patient population.

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Radiology, University of Alabama at Birmingham, 619 19th St S, NHB H623, Birmingham, AL, 35249, USA

    Benjamin J. McCafferty & Eric Bready

  2. Division of Vascular and Interventional Radiology, Department of Radiology, University of Alabama at Birmingham, 619 19th St S., Birmingham, AL, 35249, USA

    Junjian J. Huang, Husameddin El Khudari & Andrew J. Gunn

  3. University of Alabama at Birmingham School of Medicine, 1720 2nd Ave. S., Birmingham, AL, 35294, USA

    Venkata Macha

  4. Department of Urology, University of Alabama at Birmingham, 1720 2nd Ave. S., Birmingham, AL, 35294, USA

    Soroush Rais-Bahrami

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  1. Benjamin J. McCafferty
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Correspondence to Benjamin J. McCafferty.

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Conflict of interest

Dr. Gunn is speaker and consultant for Boston Scientific, a speaker for Terumo, a consultant for Varian, and receives research support from Penumbra. None of the other authors report a potential conflict of interest associated with this work and there is no grant support associated with this work.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. This study was approved by the Institutional Review Board (IRB) of the University of Alabama at Birmingham.

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McCafferty, B.J., Huang, J.J., El Khudari, H. et al. External Validation of the Renal Ablation-Specific (MC)2 Risk Scoring System in Predicting Complications from Percutaneous Renal Cryoablation. Cardiovasc Intervent Radiol 44, 1763–1768 (2021). https://doi.org/10.1007/s00270-021-02929-8

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  • DOI: https://doi.org/10.1007/s00270-021-02929-8

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