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Patterns of Reperfusion and Clinical Findings in Repeat Prostate Artery Embolisation for Recurrent Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia

  • Clinical Investigation
  • Embolisation (arterial)
  • Published:
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Abstract

Purpose

To present our experience of the patterns of revascularisation of the prostate and efficacy of repeat prostate artery embolisation (rPAE) in patients with recurrence of lower urinary tract symptoms.

Materials and Methods

We retrospectively analysed 12 patients who underwent rPAE at a single centre between November 2015 and March 2020. The patients had their intraprocedural angiography and cone beam CT images as well as their pre-procedural CT retrospectively reviewed to establish the patterns of revascularisation. Clinical follow-up occurred at a minimum of 3 months.

Results

11/12 patients (91.6%) had significant international prostate symptom score (IPSS) reduction following rPAE with change in mean IPSS from 18.4 to 8.1 at 3 months (p < 0.0001). Mean prostate volume was reduced by 41.6% (p = 0.03). 8/12 (75%) had a complete clinical success. 20/24 hemiprostates demonstrated revascularisation angiographically, of which 16 (80%) had prostatic arterial supply at rPAE by the main prostatic artery. Other mechanisms of revascularisation included supply from capsular prostatic artery branches and supply from other internal iliac pelvic branches. Unilateral embolisation at rPAE, where bilateral embolisation was not feasible (4/12), resulted in no difference in clinical outcomes compared with bilateral rPAE (p = 0.55).

Conclusion

We have found rPAE to be an effective treatment for recurrent lower urinary tract symptoms in patients who had good clinical response to initial PAE. The mechanisms of revascularisation are variable, but most patients that underwent rPAE had recanalisation of their main prostatic artery.

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This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Interventional Radiology, Churchill Hospital, Oxford University Hospitals Trust, Oxford, UK

    Daniel J. Kearns, Philip Boardman & Charles R. Tapping

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  1. Daniel J. Kearns
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  2. Philip Boardman
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Correspondence to Daniel J. Kearns.

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CRT has received research grants and consultancy fees from Boston Scientific and Merit Medical.

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Kearns, D.J., Boardman, P. & Tapping, C.R. Patterns of Reperfusion and Clinical Findings in Repeat Prostate Artery Embolisation for Recurrent Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia. Cardiovasc Intervent Radiol 44, 95–101 (2021). https://doi.org/10.1007/s00270-020-02671-7

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  • DOI: https://doi.org/10.1007/s00270-020-02671-7

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