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Introducing the New 3.5/28 Microstent Retriever for Recanalization of Distal Cerebral Arteries in Acute Stroke: Preliminary Results

  • Clinical Investigation
  • Stroke/Neurointerventions
  • Published:
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Abstract

Background and Purpose

To describe our first experience using a small stent retriever specifically designed for thrombectomy in cerebral arteries with a small caliber (Acandis APERIO® 3.5/28) in patients with acute ischemic stroke.

Materials and Methods

All patients with an acute ischemic stroke, who underwent endovascular recanalization using the APERIO® thrombectomy device with a diameter of 3.5 mm, were identified in retrospect and included in the present analysis. Demographic and clinical data as well as data on the procedures performed were collected (patient sex, mean age, NIHSS, mRS, TICI score, and complications).

Results

Stent retriever-based thrombectomy with the Aperio® 3.5/28 alone (n = 10 vessels) or in combination with other devices (n = 13 vessels) was performed in 22 acute stroke patients with embolic occlusions of distal branches of the anterior and posterior circulations (median NIHSS = 8.5). For vessels treated with the Aperio® 3.5/28, we achieved a TICI 2b/3 reperfusion rate of 73.9%. One patient suffered a symptomatic intracerebral hemorrhage after thrombectomy; otherwise, no procedure-related complications were seen.

Conclusion

Our data suggest that mechanical thrombectomy of distal cerebral artery occlusions with the Aperio® 3.5/28 is feasible and in general safe, thus offering a promising option for endovascular stroke therapy. However, multicentric studies with larger patient cohorts are necessary to evaluate the clinical benefit.

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Authors and Affiliations

  1. Institute of Neuroradiology, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528, Frankfurt, Germany

    Monika Müller-Eschner, Se-Jong You, Sara Kammerer, Arne Lauer, Joachim Berkefeld & Marlies Wagner

  2. Department of Neurology, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528, Frankfurt, Germany

    Kolja Jahnke, Christian Foerch & Waltraud Pfeilschifter

Authors
  1. Monika Müller-Eschner
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  2. Se-Jong You
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  3. Kolja Jahnke
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  4. Sara Kammerer
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  7. Arne Lauer
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  8. Joachim Berkefeld
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  9. Marlies Wagner
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Correspondence to Monika Müller-Eschner.

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Conflict of interest

Dr. Müller-Eschner has nothing to disclose. Dr. You has nothing to disclose. Dr. Jahnke has nothing to disclose. Dr. Kammerer has nothing to disclose. Dr. Foerch reports personal fees from Boehringer Ingelheim (honorarium) and Prediction Bioscience (honorarium), outside the submitted work. Dr. Pfeilschifter reports grants and personal fees from Stryker Neurovascular, grants and personal fees from Boehringer Ingelheim, personal fees from Sanofi-Aventis, grants from Novartis, outside the submitted work. Dr. Lauer has nothing to disclose. Dr. Berkefeld reports personal fees from Member of the scientific advisory board of Acandis, Pforzheim, Germany, other from Scientific cooperation with Siemens healthcare, Forchheim, Germany, outside the submitted work. Dr. Wagner reports personal fees from Acandis GmbH, during the conduct of the study.

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For this type of study, formal consent is not required. This retrospective case series analysis was approved by the institutional review board.

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Müller-Eschner, M., You, SJ., Jahnke, K. et al. Introducing the New 3.5/28 Microstent Retriever for Recanalization of Distal Cerebral Arteries in Acute Stroke: Preliminary Results. Cardiovasc Intervent Radiol 42, 101–109 (2019). https://doi.org/10.1007/s00270-018-2039-4

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  • DOI: https://doi.org/10.1007/s00270-018-2039-4

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